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Chemical Compound Review

AG-C-90743     2-(chloromethyl)phenol

Synonyms: SureCN1234540, AKOS006294222, AC1L1U7A, 1321-10-4, 40053-98-3, ...
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Disease relevance of Chlorocresol


High impact information on Chlorocresol


Chemical compound and disease context of Chlorocresol


Biological context of Chlorocresol


Anatomical context of Chlorocresol

  • Extensive electrophysiological examination without chlorocresol provocation excluded a preexisting generalised nerve disorder and other diagnostic procedures did not give evidence of pathology involving the left facial nerve [1].
  • A transient and a persistent calcium release are induced by chlorocresol in cultivated mouse myotubes [13].

Associations of Chlorocresol with other chemical compounds

  • The mean values in hertz (+/- s.d.) obtained with the photometry and high-speed digital imaging systems were: controls 8.2 +/- 0.9 and 7.9 +/- 1.1; chlorocresol 5.0 +/- 0.9 and 5.1 +/- 1.1; glycocholate 9.8 +/- 1.0 and 9.7 +/- 0 [14].
  • A flow injection analysis (FIA) procedure is described for the determination of chlorocresol in a parenteral pharmaceutical formulation [15].
  • The stability of the macrolide antibiotic erythromycin, incorporated at a 2% m/m concentration in a hydrophilic creme basis containing 2% m/m of chlorocresol, was monitored over a period of 2 months using liquid chromatography as the analytical method [16].
  • We hypothesize that the adverse cutaneous reaction was a systemic manifestation of cresol sensitivity, given the rapid clinical resolution on changing insulins and the previously demonstrated sensitivity to chlorocresol, particularly as cross-reactivity between different low molecular weight methyl phenols is documented [10].
  • In the CO2 incubator and 7- and 14-days perfusion system cultures, glycocholate (0.5%) showed a reversible cilio-stimulatory effect of 23, 26 and 21%, respectively, while chlorocresol (0.005%) exerted a reversible cilio-inhibitory effect of 36, 40 and 36%, respectively [17].

Gene context of Chlorocresol

  • Chlorocresol (0.005% w/ v) reversibly reduced the CBF of the cells by 50 +/- 6% (monolayer) and 34 +/- 4% (suspension); at a higher concentration (0.1% w/v) it resulted in instantaneous and irreversible ciliostasis [18].

Analytical, diagnostic and therapeutic context of Chlorocresol

  • Consecutive human patch tests with chlorocresol 2% in pet. showed 11 reactions among 1462 patients tested, but none were explainable and reproducible during re-tests and provocative use tests, indicating that the GPMT overestimated the sensitization potential [19].
  • The determination of the preservative, chlorocresol, in a pharmaceutical formulation by flow injection analysis [15].
  • Analytical comparison of an enzyme-amperometric method for chlorocresol determination in ointments with colorimetry and liquid chromatography [20].
  • Chlorocresol 0.1% w/v) did not meet the British Pharmacopoeial requirements for efficacy of antimicrobial preservatives when tested against C. albicans using membrane filtration to isolate the micro-organism [21].


  1. Repeated facial palsies after chlorocresol inhalation. Døssing, M., Wulff, C.H., Olsen, P.Z. J. Neurol. Neurosurg. Psychiatr. (1986) [Pubmed]
  2. Chlorocresol, an additive to commercial succinylcholine, induces contracture of human malignant hyperthermia-susceptible muscles via activation of the ryanodine receptor Ca2+ channel. Tegazzin, V., Scutari, E., Treves, S., Zorzato, F. Anesthesiology (1996) [Pubmed]
  3. Unexpected complication of successful nerve block. Morphine induced respiratory depression precipitated by removal of severe pain. Hanks, G.W., Twycross, R.G., Lloyd, J.W. Anaesthesia. (1981) [Pubmed]
  4. Contact sensitivity and bioavailability of chlorocresol. Andersen, K.E., Carlsen, L., Egsgaard, H., Larsen, E. Contact Derm. (1985) [Pubmed]
  5. Contact urticaria to chlorocresol. Freitas, J.P., Brandão, F.M. Contact Derm. (1986) [Pubmed]
  6. Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release. Zorzato, F., Scutari, E., Tegazzin, V., Clementi, E., Treves, S. Mol. Pharmacol. (1993) [Pubmed]
  7. Pentostam induces resistance to antimony and the preservative chlorocresol in Leishmania donovani promastigotes and axenically grown amastigotes. Ephros, M., Waldman, E., Zilberstein, D. Antimicrob. Agents Chemother. (1997) [Pubmed]
  8. Sarcoplasmic reticulum Ca(2+) release by 4-chloro-m-cresol (4-CmC) in intact and chemically skinned ferret cardiac ventricular fibers. Choisy, S., Huchet-Cadiou, C., Leoty, C. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  9. Chlorocresol sensitivity induced by treatment of allergic contact dermatitis with steroid creams. Archer, C.B., MacDonald, D.M. Contact Derm. (1984) [Pubmed]
  10. Severe adverse cutaneous reaction to insulin due to cresol sensitivity. Rajpar, S.F., Foulds, I.S., Abdullah, A., Maheshwari, M. Contact Derm. (2006) [Pubmed]
  11. Effect of surfactants on the antibacterial activity of preservatives. Kurup, T.R., Wan, L.S., Chan, L.W. Pharmaceutica acta Helvetiae. (1991) [Pubmed]
  12. Sensitivity and subsequent "down regulation" of sensitivity induced by chlorocresol in guinea pigs. Andersen, K.E. Arch. Dermatol. Res. (1985) [Pubmed]
  13. A transient and a persistent calcium release are induced by chlorocresol in cultivated mouse myotubes. Gschwend, M.H., Rüdel, R., Brinkmeier, H., Taylor, S.R., Föhr, K.J. Pflugers Arch. (1999) [Pubmed]
  14. High-speed digital imaging method for ciliary beat frequency measurement. Dimova, S., Maes, F., Brewster, M.E., Jorissen, M., Noppe, M., Augustijns, P. J. Pharm. Pharmacol. (2005) [Pubmed]
  15. The determination of the preservative, chlorocresol, in a pharmaceutical formulation by flow injection analysis. Bloomfield, M.S., Prebble, K.A. Journal of pharmaceutical and biomedical analysis. (1992) [Pubmed]
  16. Study of the stability of erythromycin in a hydrophilic creme basis by liquid chromatography. Paesen, J., Roets, E., Hoogmartens, J. Journal of pharmaceutical and biomedical analysis. (1998) [Pubmed]
  17. Stable ciliary activity in human nasal epithelial cells grown in a perfusion system. Dimova, S., Vlaeminck, V., Brewster, M.E., Noppe, M., Jorissen, M., Augustijns, P. International journal of pharmaceutics. (2005) [Pubmed]
  18. Effects of pharmaceutical compounds on ciliary beating in human nasal epithelial cells: a comparative study of cell culture models. Agu, R.U., Jorissen, M., Willems, T., Van den Mooter, G., Kinget, R., Augustijns, P. Pharm. Res. (1999) [Pubmed]
  19. How sensitizing is chlorocresol? Allergy tests in guinea pigs versus the clinical experience. Andersen, K.E., Hamann, K. Contact Derm. (1984) [Pubmed]
  20. Analytical comparison of an enzyme-amperometric method for chlorocresol determination in ointments with colorimetry and liquid chromatography. Campanella, L., Sammartino, M.P., Sbrilli, R., Tomassetti, M. Journal of pharmaceutical and biomedical analysis. (1992) [Pubmed]
  21. A note on the recovery of micro-organisms from an oil-in-water cream. Brown, M.W., Evans, C., Ford, J.L., Pilling, M. Journal of clinical and hospital pharmacy. (1986) [Pubmed]
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