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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2.

Several cytochrome P-450 enzymes are able to hydroxylate testosterone to many different metabolites, some of which remain to be identified. One hitherto unidentified metabolite represents a major metabolite of P-450 2A2, present in the liver of adult male rats, and a minor metabolite of several other cytochrome P-450 enzymes. Using the techniques of HPLC and GC/MS, we have obtained unequivocal evidence that this metabolite is 12 alpha-hydroxytestosterone.[1]

References

  1. 12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2. Smith, S.J., Korzekwa, K.R., Aoyama, T., Gonzalez, F.J., Darbyshire, J.F., Sugiyama, K., Gillette, J.R. Drug Metab. Dispos. (1992) [Pubmed]
 
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