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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cocaine decreases self-control in rats: a preliminary report.

Cocaine abuse is often associated with behavior that takes into account short-term, but not long-term consequences. However, there has been no empirical research concerning the effects of cocaine on self-control (choice of a larger, more delayed reinforcer over a smaller, less delayed reinforcer). In the present research, when food-deprived rats repeatedly chose between a larger, more delayed food reinforcer and a smaller, less delayed food reinforcer, chronic intraperitoneal injections of 15 mg/kg cocaine (but not 10 mg/kg fluoxetine) decreased the rats' choices of the larger, more delayed reinforcer. Cocaine can decrease rats' self-control.[1]


  1. Cocaine decreases self-control in rats: a preliminary report. Logue, A.W., Tobin, H., Chelonis, J.J., Wang, R.Y., Geary, N., Schachter, S. Psychopharmacology (Berl.) (1992) [Pubmed]
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