The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Fluoxetin     N-methyl-3-phenyl-3-[4...

Synonyms: Pulvules, Reneuron, Floxetine, Fluoxeren, Foxetin, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Prozac


Psychiatry related information on Prozac


High impact information on Prozac

  • The results were similar in children exposed to a tricyclic antidepressant drug or fluoxetine during the first trimester and those exposed throughout pregnancy [6].
  • CONCLUSION: Women who take fluoxetine during pregnancy do not have an increased risk of spontaneous pregnancy loss or major fetal anomalies, but women who take fluoxetine in the third trimester are at increased risk for perinatal complications [2].
  • The trial consisted of a single-blind, placebo washout period lasting two menstrual cycles, followed by a randomized, double-blind, placebo-controlled trial of fluoxetine at a dose of either 20 mg or 60 mg per day or placebo for six menstrual cycles [10].
  • Transfection with a single 2.3-kilobase brainstem complementary DNA clone is sufficient to confer expression of a Na(+)-dependent 5HT transporter upon nonneural cells, with transport selectively and potently antagonized by 5HT uptake-specific antidepressants, including paroxetine, citalopram and fluoxetine [11].
  • Silver grain density was increased over cells positive for glial fibrillary acidic protein and was reduced to background levels when sodium was omitted from the medium or the specific inhibitors of serotonin uptake fluoxetine and chlorimipramine were present [12].

Chemical compound and disease context of Prozac


Biological context of Prozac


Anatomical context of Prozac


Associations of Prozac with other chemical compounds


Gene context of Prozac


Analytical, diagnostic and therapeutic context of Prozac

  • RESULTS: The mean (+/-SD) global IQ scores were 118+/-17 in the children of mothers who received a tricyclic antidepressant drug, 117+/-17 in those whose mothers received fluoxetine, and 115+/-14 in those in the control group [6].
  • After individual dose titration, the mean daily doses of the drugs were as follows: amitriptyline, 105 mg; desipramine, 111 mg; and fluoxetine, 40 mg [3].
  • Fluoxetine at a dose of 20 or 60 mg per day was significantly superior to placebo in reducing symptoms of tension, irritability, and dysphoria, as measured by the visual-analogue scales (P < 0.001) [10].
  • DESIGN--We prospectively collected and followed up 128 pregnant women exposed to a mean daily dose of 25.8 mg (+/- 13 mg) of fluoxetine during the first trimester and compared pregnancy outcome with two matched groups of women exposed during the first trimester of pregnancy to either nonteratogens or tricyclic antidepressants [5].
  • Among prescription drug users, 16% also took an herbal/supplement; the rate of concurrent use was highest for fluoxetine users, at 22% [35].


  1. Fluoxetine. Gram, L. N. Engl. J. Med. (1994) [Pubmed]
  2. Birth outcomes in pregnant women taking fluoxetine. Chambers, C.D., Johnson, K.A., Dick, L.M., Felix, R.J., Jones, K.L. N. Engl. J. Med. (1996) [Pubmed]
  3. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. Max, M.B., Lynch, S.A., Muir, J., Shoaf, S.E., Smoller, B., Dubner, R. N. Engl. J. Med. (1992) [Pubmed]
  4. Fluoxetine and fibromyalgia. Finestone, D.H., Ober, S.K. JAMA (1990) [Pubmed]
  5. Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac). Pastuszak, A., Schick-Boschetto, B., Zuber, C., Feldkamp, M., Pinelli, M., Sihn, S., Donnenfeld, A., McCormack, M., Leen-Mitchell, M., Woodland, C. JAMA (1993) [Pubmed]
  6. Neurodevelopment of children exposed in utero to antidepressant drugs. Nulman, I., Rovet, J., Stewart, D.E., Wolpin, J., Gardner, H.A., Theis, J.G., Kulin, N., Koren, G. N. Engl. J. Med. (1997) [Pubmed]
  7. Randomised, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome. Vercoulen, J.H., Swanink, C.M., Zitman, F.G., Vreden, S.G., Hoofs, M.P., Fennis, J.F., Galama, J.M., van der Meer, J.W., Bleijenberg, G. Lancet (1996) [Pubmed]
  8. A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder. Tollefson, G.D., Rampey, A.H., Potvin, J.H., Jenike, M.A., Rush, A.J., kominguez, R.A., Koran, L.M., Shear, M.K., Goodman, W., Genduso, L.A. Arch. Gen. Psychiatry (1994) [Pubmed]
  9. Clinical improvement with fluoxetine therapy and noradrenergic function in patients with panic disorder. Coplan, J.D., Papp, L.A., Pine, D., Martinez, J., Cooper, T., Rosenblum, L.A., Klein, D.F., Gorman, J.M. Arch. Gen. Psychiatry (1997) [Pubmed]
  10. Fluoxetine in the treatment of premenstrual dysphoria. Canadian Fluoxetine/Premenstrual Dysphoria Collaborative Study Group. Steiner, M., Steinberg, S., Stewart, D., Carter, D., Berger, C., Reid, R., Grover, D., Streiner, D. N. Engl. J. Med. (1995) [Pubmed]
  11. Cloning and expression of a functional serotonin transporter from rat brain. Blakely, R.D., Berson, H.E., Fremeau, R.T., Caron, M.G., Peek, M.M., Prince, H.K., Bradley, C.C. Nature (1991) [Pubmed]
  12. High-affinity uptake of serotonin into immunocytochemically identified astrocytes. Kimelberg, H.K., Katz, D.M. Science (1985) [Pubmed]
  13. MPTP-induced duodenal ulcers in rat. Prevention by reuptake blockers for serotonin and norepinephrine, but not dopamine. Keshavarzian, A., Wibowo, A., Gordon, J.H., Fields, J.Z. Gastroenterology (1990) [Pubmed]
  14. The portal pressure response to beta-blockade is greater in cirrhotic patients without varices than in those with varices. Escorsell, A., Ferayorni, L., Bosch, J., García-Pagán, J.C., García-Tsao, G., Grace, N.D., Rodés, J., Groszmann, R.J. Gastroenterology (1997) [Pubmed]
  15. Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations. Laine, K., Heikkinen, T., Ekblad, U., Kero, P. Arch. Gen. Psychiatry (2003) [Pubmed]
  16. Propranolol in the prevention of the first hemorrhage from esophagogastric varices: A multicenter, randomized clinical trial. The Boston-New Haven-Barcelona Portal Hypertension Study Group. Conn, H.O., Grace, N.D., Bosch, J., Groszmann, R.J., Rodés, J., Wright, S.C., Matloff, D.S., Garcia-Tsao, G., Fisher, R.L., Navasa, M. Hepatology (1991) [Pubmed]
  17. Phase III evaluation of fluoxetine for treatment of hot flashes. Loprinzi, C.L., Sloan, J.A., Perez, E.A., Quella, S.K., Stella, P.J., Mailliard, J.A., Halyard, M.Y., Pruthi, S., Novotny, P.J., Rummans, T.A. J. Clin. Oncol. (2002) [Pubmed]
  18. Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats. Wurtman, J.J., Wurtman, R.J. Science (1977) [Pubmed]
  19. Portal hypertension enhances endotoxin-induced intercellular adhesion molecule 1 up-regulation in the rat. Panés, J., Perry, M.A., Anderson, D.C., Muzykantov, V.R., Carden, D.L., Miyasaka, M., Granger, D.N. Gastroenterology (1996) [Pubmed]
  20. Distorted microangioarchitecture and impaired angiogenesis in gastric mucosa of portal hypertensive rats. Ichikawa, Y., Tarnawski, A., Sarfeh, I.J., Ishikawa, T., Shimada, H. Gastroenterology (1994) [Pubmed]
  21. Modulation of ionic currents in isolated canine and human jejunal circular smooth muscle cells by fluoxetine. Farrugia, G. Gastroenterology (1996) [Pubmed]
  22. Overexpressed nitric oxide synthase in portal-hypertensive stomach of rat: a key to increased susceptibility to damage? Ohta, M., Tanoue, K., Tarnawski, A.S., Pai, R., Itani, R.M., Sander, F.C., Sugimachi, K., Sarfeh, I.J. Gastroenterology (1997) [Pubmed]
  23. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Tanoue, K., Ohta, M., Tarnawski, A.S., Wahlstrom, K.J., Sugimachi, K., Sarfeh, I.J. Gastroenterology (1996) [Pubmed]
  24. Similar effectiveness of paroxetine, fluoxetine, and sertraline in primary care: a randomized trial. Kroenke, K., West, S.L., Swindle, R., Gilsenan, A., Eckert, G.J., Dolor, R., Stang, P., Zhou, X.H., Hays, R., Weinberger, M. JAMA (2001) [Pubmed]
  25. Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort. Tiihonen, J., L??nnqvist, J., Wahlbeck, K., Klaukka, T., Tanskanen, A., Haukka, J. Arch. Gen. Psychiatry (2006) [Pubmed]
  26. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Uzunova, V., Sheline, Y., Davis, J.M., Rasmusson, A., Uzunov, D.P., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  27. Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac). Svenningsson, P., Tzavara, E.T., Witkin, J.M., Fienberg, A.A., Nomikos, G.G., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  28. Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex. Varea, E., Blasco-Ibáñez, J.M., Gómez-Climent, M.A., Castillo-Gómez, E., Crespo, C., Martínez-Guijarro, F.J., Nácher, J. Neuropsychopharmacology (2007) [Pubmed]
  29. Overlapping and distinct brain regions associated with the anxiolytic effects of chlordiazepoxide and chronic fluoxetine. Bechtholt, A.J., Valentino, R.J., Lucki, I. Neuropsychopharmacology (2008) [Pubmed]
  30. Fluoxetine inhibits multidrug resistance extrusion pumps and enhances responses to chemotherapy in syngeneic and in human xenograft mouse tumor models. Peer, D., Dekel, Y., Melikhov, D., Margalit, R. Cancer Res. (2004) [Pubmed]
  31. Investigation of serotonin-related genes in antidepressant response. Peters, E.J., Slager, S.L., McGrath, P.J., Knowles, J.A., Hamilton, S.P. Mol. Psychiatry (2004) [Pubmed]
  32. Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans. Licinio, J., O'Kirwan, F., Irizarry, K., Merriman, B., Thakur, S., Jepson, R., Lake, S., Tantisira, K.G., Weiss, S.T., Wong, M.L. Mol. Psychiatry (2004) [Pubmed]
  33. Pharmacokinetics of selective serotonin reuptake inhibitors. Hiemke, C., Härtter, S. Pharmacol. Ther. (2000) [Pubmed]
  34. Prediction of In Vivo Drug-Drug Interactions from In Vitro Data : Factors Affecting Prototypic Drug-Drug Interactions Involving CYP2C9, CYP2D6 and CYP3A4. Brown, H.S., Galetin, A., Hallifax, D., Houston, J.B. Clinical pharmacokinetics. (2006) [Pubmed]
  35. Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. Kaufman, D.W., Kelly, J.P., Rosenberg, L., Anderson, T.E., Mitchell, A.A. JAMA (2002) [Pubmed]
WikiGenes - Universities