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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

One explanation for F1 antiparent responses.

The phenomenon of hybrid resistance, in which F1 offspring reject parental grafts, remains a perplexing problem. Here, Tina Dalianis and Lars Ahrlund-Richter propose that one component of the F1 antiparent response results from competition between the two sets of parentally derived major histocompatibility complex (MHC) molecules for 'promiscuous' peptides. Lack of tolerance in the F1 animal results from insufficient presentation of these peptides on the MHC molecule that has lower affinity for the peptides.[1]


  1. One explanation for F1 antiparent responses. Dalianis, T., Ahrlund-Richter, L. Immunol. Today (1992) [Pubmed]
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