Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5.
IL-16 binds to CD4 and induces a migratory response in CD4(+) T cells. Although it has been assumed that CD4 is the sole receptor and that IL-16 induces a comparable migratory response in all CD4(+) T cells, this has not been investigated. In this study, we determined that IL-16 preferentially induces a migratory response in Th1 cells. Because chemokine receptor CCR5 is expressed predominantly in Th1 cells and is physically associated with CD4, we investigated whether IL-16/CD4 stimulation was enhanced in the presence of CCR5. Using T cells from CCR5(null) mice, we determined that IL-16- induced migration was significantly greater in the presence of CCR5. The presence of CCR5 significantly increased IL-16 binding vs CD4 alone; however, IL-16 could not bind to CCR5 alone. Because CD4(+)CCR5(+) cells are prevalent at sites of inflammation, this intimate functional relationship likely plays a pivotal role for the recruitment and activation of Th1 cells.[1]References
- Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. Lynch, E.A., Heijens, C.A., Horst, N.F., Center, D.M., Cruikshank, W.W. J. Immunol. (2003) [Pubmed]
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