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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Endophilin and synaptojanin hook up to promote synaptic vesicle endocytosis.

Clathrin-mediated endocytosis of synaptic vesicles requires molecular rearrangements of proteins as well as lipids. In this issue of Neuron, Schuske et al. and Verstreken et al. show that the lipid-modifying enzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve terminals. This remarkable pairing of two enzymatic activities promotes multiple steps of clathrin-mediated endocytosis of synaptic vesicles.[1]


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