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MeSH Review

Synaptic Vesicles

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Disease relevance of Synaptic Vesicles


Psychiatry related information on Synaptic Vesicles


High impact information on Synaptic Vesicles

  • Our data suggest that Vha100-1 functions downstream of SNAREs in synaptic vesicle fusion [9].
  • Alpha-synuclein and cysteine-string protein-alpha (CSPalpha) are abundant synaptic vesicle proteins independently linked to neurodegeneration [10].
  • Using clustering of synaptic vesicles in cultured neurons as an assay, we purified putative target-derived presynaptic organizing molecules from mouse brain and identified FGF22 as a major active species [11].
  • Ca2+ sensor/effector complexes consisting of calmodulin and Munc13s regulate synaptic vesicle priming and synaptic efficacy in response to a residual [Ca2+] signal and thus shape short-term plasticity characteristics during periods of sustained synaptic activity [12].
  • We report here a direct interaction between voltage-gated Ca2+ channels and endophilin, a key regulator of clathrin-mediated synaptic vesicle endocytosis [13].

Chemical compound and disease context of Synaptic Vesicles


Biological context of Synaptic Vesicles


Anatomical context of Synaptic Vesicles


Associations of Synaptic Vesicles with chemical compounds


Gene context of Synaptic Vesicles

  • Rab3a is the most abundant Rab (ras-associated binding) protein in the brain and has a regulatory role in synaptic vesicle trafficking [28].
  • The phenotype of the synapsin knockouts could be explained either by deficient recruitment of synaptic vesicles to the active zone, or by impaired maturation of vesicles at the active zone, both of which could lead to a secondary destabilization of synaptic vesicles [29].
  • Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein [30].
  • In the absence of synaptobrevin 2, spontaneous synaptic vesicle fusion and fusion induced by hypertonic sucrose were decreased approximately 10-fold, but fast Ca2+-triggered fusion was decreased more than 100-fold [31].
  • On the basis of sequence similarity to mammalian vesicular transporters of biogenic amines and of localization to synaptic vesicles of cholinergic neurons in C. elegans, unc-17 likely encodes the vesicular transporter of acetylcholine [32].

Analytical, diagnostic and therapeutic context of Synaptic Vesicles


  1. Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin. Blasi, J., Chapman, E.R., Yamasaki, S., Binz, T., Niemann, H., Jahn, R. EMBO J. (1993) [Pubmed]
  2. Impairment of inhibitory synaptic transmission in mice lacking synapsin I. Terada, S., Tsujimoto, T., Takei, Y., Takahashi, T., Hirokawa, N. J. Cell Biol. (1999) [Pubmed]
  3. Peptide mapping of the [125I]Iodoazidoketanserin and [125I]2-N-[(3'-iodo-4'-azidophenyl)propionyl]tetrabenazine binding sites for the synaptic vesicle monoamine transporter. Sievert, M.K., Ruoho, A.E. J. Biol. Chem. (1997) [Pubmed]
  4. Neuroepithelial oxygen chemoreceptors of the zebrafish gill. Jonz, M.G., Fearon, I.M., Nurse, C.A. J. Physiol. (Lond.) (2004) [Pubmed]
  5. Tubulin: an integral protein of mammalian synaptic vesicle membranes. Zisapel, N., Levi, M., Gozes, I. J. Neurochem. (1980) [Pubmed]
  6. Differences in L-[3H]glutamate accumulation and endogenous L-glutamate content in synaptic vesicles from mice selectively bred for differences in ethanol sensitivity. Disbrow, J.K., Ruth, J.A. J. Neurochem. (1985) [Pubmed]
  7. Mice deficient for the synaptic vesicle protein Rab3a show impaired spatial reversal learning and increased explorative activity but none of the behavioral changes shown by mice deficient for the Rab3a regulator Gdi1. D'Adamo, P., Wolfer, D.P., Kopp, C., Tobler, I., Toniolo, D., Lipp, H.P. Eur. J. Neurosci. (2004) [Pubmed]
  8. Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique. Ho, L., Guo, Y., Spielman, L., Petrescu, O., Haroutunian, V., Purohit, D., Czernik, A., Yemul, S., Aisen, P.S., Mohs, R., Pasinetti, G.M. Neurosci. Lett. (2001) [Pubmed]
  9. The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Hiesinger, P.R., Fayyazuddin, A., Mehta, S.Q., Rosenmund, T., Schulze, K.L., Zhai, R.G., Verstreken, P., Cao, Y., Zhou, Y., Kunz, J., Bellen, H.J. Cell (2005) [Pubmed]
  10. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Chandra, S., Gallardo, G., Fernández-Chacón, R., Schlüter, O.M., Südhof, T.C. Cell (2005) [Pubmed]
  11. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Umemori, H., Linhoff, M.W., Ornitz, D.M., Sanes, J.R. Cell (2004) [Pubmed]
  12. Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity. Junge, H.J., Rhee, J.S., Jahn, O., Varoqueaux, F., Spiess, J., Waxham, M.N., Rosenmund, C., Brose, N. Cell (2004) [Pubmed]
  13. Formation of an endophilin-Ca2+ channel complex is critical for clathrin-mediated synaptic vesicle endocytosis. Chen, Y., Deng, L., Maeno-Hikichi, Y., Lai, M., Chang, S., Chen, G., Zhang, J.F. Cell (2003) [Pubmed]
  14. Role of zinc in plasma membrane function. O'Dell, B.L. J. Nutr. (2000) [Pubmed]
  15. Rabies virus entry into cultured rat hippocampal neurons. Lewis, P., Lentz, T.L. J. Neurocytol. (1998) [Pubmed]
  16. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Wiedenmann, B., Franke, W.W. Cell (1985) [Pubmed]
  17. A targeting signal in VAMP regulating transport to synaptic vesicles. Grote, E., Hao, J.C., Bennett, M.K., Kelly, R.B. Cell (1995) [Pubmed]
  18. Synapsin I bundles F-actin in a phosphorylation-dependent manner. Bähler, M., Greengard, P. Nature (1987) [Pubmed]
  19. The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Geppert, M., Goda, Y., Stevens, C.F., Südhof, T.C. Nature (1997) [Pubmed]
  20. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Okada, Y., Yamazaki, H., Sekine-Aizawa, Y., Hirokawa, N. Cell (1995) [Pubmed]
  21. Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling. Zhang, J.Z., Davletov, B.A., Südhof, T.C., Anderson, R.G. Cell (1994) [Pubmed]
  22. Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans. Jorgensen, E.M., Hartwieg, E., Schuske, K., Nonet, M.L., Jin, Y., Horvitz, H.R. Nature (1995) [Pubmed]
  23. Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion. Hu, K., Carroll, J., Fedorovich, S., Rickman, C., Sukhodub, A., Davletov, B. Nature (2002) [Pubmed]
  24. Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cremona, O., Di Paolo, G., Wenk, M.R., Lüthi, A., Kim, W.T., Takei, K., Daniell, L., Nemoto, Y., Shears, S.B., Flavell, R.A., McCormick, D.A., De Camilli, P. Cell (1999) [Pubmed]
  25. Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons. Takamori, S., Rhee, J.S., Rosenmund, C., Jahn, R. Nature (2000) [Pubmed]
  26. Proton NMR detection of acetylcholine status in synaptic vesicles. Stadler, H., Füldner, H.H. Nature (1980) [Pubmed]
  27. Identification and characterization of the vesicular GABA transporter. McIntire, S.L., Reimer, R.J., Schuske, K., Edwards, R.H., Jorgensen, E.M. Nature (1997) [Pubmed]
  28. Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Kapfhamer, D., Valladares, O., Sun, Y., Nolan, P.M., Rux, J.J., Arnold, S.E., Veasey, S.C., Bućan, M. Nat. Genet. (2002) [Pubmed]
  29. Essential functions of synapsins I and II in synaptic vesicle regulation. Rosahl, T.W., Spillane, D., Missler, M., Herz, J., Selig, D.K., Wolff, J.R., Hammer, R.E., Malenka, R.C., Südhof, T.C. Nature (1995) [Pubmed]
  30. Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein. McMahon, H.T., Ushkaryov, Y.A., Edelmann, L., Link, E., Binz, T., Niemann, H., Jahn, R., Südhof, T.C. Nature (1993) [Pubmed]
  31. SNARE function analyzed in synaptobrevin/VAMP knockout mice. Schoch, S., Deák, F., Königstorfer, A., Mozhayeva, M., Sara, Y., Südhof, T.C., Kavalali, E.T. Science (2001) [Pubmed]
  32. The Caenorhabditis elegans unc-17 gene: a putative vesicular acetylcholine transporter. Alfonso, A., Grundahl, K., Duerr, J.S., Han, H.P., Rand, J.B. Science (1993) [Pubmed]
  33. Synapsin I in nerve terminals: selective association with small synaptic vesicles. Navone, F., Greengard, P., De Camilli, P. Science (1984) [Pubmed]
  34. Synapsin I partially dissociates from synaptic vesicles during exocytosis induced by electrical stimulation. Torri Tarelli, F., Bossi, M., Fesce, R., Greengard, P., Valtorta, F. Neuron (1992) [Pubmed]
  35. Amphiphysin, a novel protein associated with synaptic vesicles. Lichte, B., Veh, R.W., Meyer, H.E., Kilimann, M.W. EMBO J. (1992) [Pubmed]
  36. Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue. Matthew, W.D., Tsavaler, L., Reichardt, L.F. J. Cell Biol. (1981) [Pubmed]
  37. Cloning and sequence analysis of cDNA encoding p38, a major synaptic vesicle protein. Buckley, K.M., Floor, E., Kelly, R.B. J. Cell Biol. (1987) [Pubmed]
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