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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death.

In brain ischemia, gating of postsynaptic glutamate receptors is thought to initiate Ca2+ overload leading to excitotoxic neuronal death. In this issue, Aarts and colleagues describe a novel mechanism, whereby gating of TRPM7, a Ca2+-permeable nonselective cation channel, mediates Ca2+ overload and demise of anoxic neurons.[1]

References

  1. The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death. Nicotera, P., Bano, D. Cell (2003) [Pubmed]
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