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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A novel series of potent and selective IKK2 inhibitors.

A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.[1]

References

  1. A novel series of potent and selective IKK2 inhibitors. Bingham, A.H., Davenport, R.J., Gowers, L., Knight, R.L., Lowe, C., Owen, D.A., Parry, D.M., Pitt, W.R. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
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