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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

BRCA2-RAD51-DSS1 interplay examined from a microbial perspective.

The tumor suppressor BRCA2 plays an essential role in the repair of double-strand DNA breaks by regulating the action of the RAD51 recombinase. The activity of BRCA2 is in turn governed by DSS1, a small acidic protein that appears to function as a necessary cofactor. A model fungal system that reproduces the BRCA2-RAD51 interaction offers the opportunity to understand the mechanism of DSS1 activation at the molecular level.[1]


  1. BRCA2-RAD51-DSS1 interplay examined from a microbial perspective. Kojic, M., Holloman, W.K. Cell Cycle (2004) [Pubmed]
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