Gene Review:
BRCA2 - breast cancer 2, early onset
Homo sapiens
Synonyms:
BRCC2, BROVCA2, Breast cancer type 2 susceptibility protein, FACD, FAD, ...
Deloukas,
Clegg,
Story,
Ashwell,
Kuenen-Boumeester,
Earthrowl,
West,
Bird,
Wilming,
Diez,
Searle,
Burrill,
Wray,
Faulkner,
Keenan,
Brown,
Tester,
Burton,
Buchholz,
Schnieden,
Wright,
Gilbert,
Sarrió,
Ashcroft,
Steward,
Young,
John,
Whittemore,
Tracey,
Brown,
Mashreghi-Mohammadi,
Butow,
Oliver,
Haile,
Leongamornlert,
Mills,
Howden,
Thomas,
Lloyd,
Kenemans,
Ward,
Whitehead,
Friedlander,
Dhami,
Wall,
Ghori,
Lloyd,
Cazorla,
Tubby,
Clee,
Heath,
Scott,
Hussain,
Laird,
Carter,
Boyd,
Meijer-Heijboer,
Grafham,
Gilson,
Garnett,
Bannerjee,
Sánchez,
Lovell,
Holden,
Milne,
Tran,
Ellington,
Bailey,
Chapman,
Alonso,
Meiser,
Kimberley,
Hunt,
Martin,
Daly,
Rivas,
Phillimore,
Dunham,
Ross,
Cobley,
Jenkins,
Brock,
Barratt,
Southey,
Clark,
Osorio,
Timmermans,
Burford,
Corby,
Hopper,
Griffiths,
Babbage,
Garner,
Avizonis,
Berns,
Ambrose,
Smith,
Hall,
French,
Griffiths-Jones,
Huckle,
Sehra,
Coville,
Verheijen,
Carder,
Klijn,
Verstraeten,
Frankish,
Elledge,
Terry,
Dunn,
Hunt,
Felberg,
Dirkzwager-Kiel,
Nickerson,
Bergh,
Smith,
Geara,
Barroso,
Watson,
Gaffney,
van den Ouweland,
Beasley,
Langford,
Shownkeen,
McLaren,
Beare,
Haffty,
Johnson,
Clarke,
Verhoog,
Andrulis,
Tucker,
McGuire,
Bentley,
Willey,
Gribble,
Rodríguez,
Cigudosa,
Bray-Allen,
Beck,
Hammond,
Hart,
Marshall,
Sulston,
Porter,
Pelan,
Bates,
Rogers,
Palacios,
Milne,
Frankland,
Wu,
Ainscough,
Johnson,
West,
Almeida,
Bagguley,
Lawlor,
Neuhausen,
Benítez,
Hunt,
Ashurst,
Barlow,
Tucker,
Knight,
Godwin,
Moore,
Durbin,
Hubbard,
Hemmersmeier,
Lerma,
Honrado,
van der Kwast,
King,
Collins,
Harley,
Dunham,
Rice,
Andrews,
Sycamore,
Wallis,
Peck,
Loveland,
Giles,
Clamp,
Chang,
Jones,
Skuce,
Pearce,
Coulson,
Tromans,
Thomas,
Matthews,
Brown,
Palmer,
Howe,
Kay,
McMurray,
- Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Jonkers, J., Meuwissen, R., van der Gulden, H., Peterse, H., van der Valk, M., Berns, A. Nat. Genet. (2001)
- Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Meijers-Heijboer, H., van den Ouweland, A., Klijn, J., Wasielewski, M., de Snoo, A., Oldenburg, R., Hollestelle, A., Houben, M., Crepin, E., van Veghel-Plandsoen, M., Elstrodt, F., van Duijn, C., Bartels, C., Meijers, C., Schutte, M., McGuffog, L., Thompson, D., Easton, D., Sodha, N., Seal, S., Barfoot, R., Mangion, J., Chang-Claude, J., Eccles, D., Eeles, R., Evans, D.G., Houlston, R., Murday, V., Narod, S., Peretz, T., Peto, J., Phelan, C., Zhang, H.X., Szabo, C., Devilee, P., Goldgar, D., Futreal, P.A., Nathanson, K.L., Weber, B., Rahman, N., Stratton, M.R. Nat. Genet. (2002)
- A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Meetei, A.R., Medhurst, A.L., Ling, C., Xue, Y., Singh, T.R., Bier, P., Steltenpool, J., Stone, S., Dokal, I., Mathew, C.G., Hoatlin, M., Joenje, H., de Winter, J.P., Wang, W. Nat. Genet. (2005)
- Brca2 is involved in meiosis in Arabidopsis thaliana as suggested by its interaction with Dmc1. Siaud, N., Dray, E., Gy, I., Gérard, E., Takvorian, N., Doutriaux, M.P. EMBO J. (2004)
- Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-dependent probe amplification is common in prostate cancers from men with a germline BRCA2 mutation. Willems, A.J., Dawson, S.J., Samaratunga, H., De Luca, A., Antill, Y.C., Hopper, J.L., Thorne, H.J. Clin. Cancer Res. (2008)
- Clinical management of women with genomic BRCA1 and BRCA2 mutations. Chang, J., Elledge, R.M. Breast Cancer Res. Treat. (2001)
- BRCA1 and BRCA2 gene mutations: decision-making dilemmas concerning testing and management. Fasouliotis, S.J., Schenker, J.G. Obstetrical & gynecological survey. (2000)
- The DNA sequence and analysis of human chromosome 13. Dunham, A., Matthews, L.H., Burton, J., Ashurst, J.L., Howe, K.L., Ashcroft, K.J., Beare, D.M., Burford, D.C., Hunt, S.E., Griffiths-Jones, S., Jones, M.C., Keenan, S.J., Oliver, K., Scott, C.E., Ainscough, R., Almeida, J.P., Ambrose, K.D., Andrews, D.T., Ashwell, R.I., Babbage, A.K., Bagguley, C.L., Bailey, J., Bannerjee, R., Barlow, K.F., Bates, K., Beasley, H., Bird, C.P., Bray-Allen, S., Brown, A.J., Brown, J.Y., Burrill, W., Carder, C., Carter, N.P., Chapman, J.C., Clamp, M.E., Clark, S.Y., Clarke, G., Clee, C.M., Clegg, S.C., Cobley, V., Collins, J.E., Corby, N., Coville, G.J., Deloukas, P., Dhami, P., Dunham, I., Dunn, M., Earthrowl, M.E., Ellington, A.G., Faulkner, L., Frankish, A.G., Frankland, J., French, L., Garner, P., Garnett, J., Gilbert, J.G., Gilson, C.J., Ghori, J., Grafham, D.V., Gribble, S.M., Griffiths, C., Hall, R.E., Hammond, S., Harley, J.L., Hart, E.A., Heath, P.D., Howden, P.J., Huckle, E.J., Hunt, P.J., Hunt, A.R., Johnson, C., Johnson, D., Kay, M., Kimberley, A.M., King, A., Laird, G.K., Langford, C.J., Lawlor, S., Leongamornlert, D.A., Lloyd, D.M., Lloyd, C., Loveland, J.E., Lovell, J., Martin, S., Mashreghi-Mohammadi, M., McLaren, S.J., McMurray, A., Milne, S., Moore, M.J., Nickerson, T., Palmer, S.A., Pearce, A.V., Peck, A.I., Pelan, S., Phillimore, B., Porter, K.M., Rice, C.M., Searle, S., Sehra, H.K., Shownkeen, R., Skuce, C.D., Smith, M., Steward, C.A., Sycamore, N., Tester, J., Thomas, D.W., Tracey, A., Tromans, A., Tubby, B., Wall, M., Wallis, J.M., West, A.P., Whitehead, S.L., Willey, D.L., Wilming, L., Wray, P.W., Wright, M.W., Young, L., Coulson, A., Durbin, R., Hubbard, T., Sulston, J.E., Beck, S., Bentley, D.R., Rogers, J., Ross, M.T. Nature (2004)
- No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years. McGuire, V., John, E.M., Felberg, A., Haile, R.W., Boyd, N.F., Thomas, D.C., Jenkins, M.A., Milne, R.L., Daly, M.B., Ward, J., Terry, M.B., Andrulis, I.L., Knight, J.A., Godwin, A.K., Giles, G.G., Southey, M., West, D.W., Hopper, J.L., Whittemore, A.S. Cancer Epidemiol. Biomarkers Prev. (2006)
- Psychological impact of genetic testing in women from high-risk breast cancer families. Meiser, B., Butow, P., Friedlander, M., Barratt, A., Schnieden, V., Watson, M., Brown, J., Tucker, K. Eur. J. Cancer (2002)
- Epithelial ovarian cancer: prevention, diagnosis, and treatment. Partridge, E.E., Barnes, M.N. CA: a cancer journal for clinicians. (1999)
- Fanconi anemia and breast cancer susceptibility. Patel, K.J. Nat. Genet. (2007)
- Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Reid, S., Schindler, D., Hanenberg, H., Barker, K., Hanks, S., Kalb, R., Neveling, K., Kelly, P., Seal, S., Freund, M., Wurm, M., Batish, S.D., Lach, F.P., Yetgin, S., Neitzel, H., Ariffin, H., Tischkowitz, M., Mathew, C.G., Auerbach, A.D., Rahman, N. Nat. Genet. (2007)
- Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Xia, B., Dorsman, J.C., Ameziane, N., de Vries, Y., Rooimans, M.A., Sheng, Q., Pals, G., Errami, A., Gluckman, E., Llera, J., Wang, W., Livingston, D.M., Joenje, H., de Winter, J.P. Nat. Genet. (2007)
- Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Seal, S., Thompson, D., Renwick, A., Elliott, A., Kelly, P., Barfoot, R., Chagtai, T., Jayatilake, H., Ahmed, M., Spanova, K., North, B., McGuffog, L., Evans, D.G., Eccles, D., Easton, D.F., Stratton, M.R., Rahman, N. Nat. Genet. (2006)
- BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription. Shin, S., Verma, I.M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene. Hughes, D.J., Ginolhac, S.M., Coupier, I., Barjhoux, L., Gaborieau, V., Bressac-de-Paillerets, B., Chompret, A., Bignon, Y.J., Uhrhammer, N., Lasset, C., Giraud, S., Sobol, H., Hardouin, A., Berthet, P., Peyrat, J.P., Fournier, J., Nogues, C., Lidereau, R., Muller, D., Fricker, J.P., Longy, M., Toulas, C., Guimbaud, R., Yannoukakos, D., Mazoyer, S., Lynch, H.T., Lenoir, G.M., Goldgar, D.E., Stoppa-Lyonnet, D., Sinilnikova, O.M. Int. J. Cancer (2005)
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Fan, S., Meng, Q., Auborn, K., Carter, T., Rosen, E.M. Br. J. Cancer (2006)
- Life expectancy gains from cancer prevention strategies for women with breast cancer and BRCA1 or BRCA2 mutations. Schrag, D., Kuntz, K.M., Garber, J.E., Weeks, J.C. JAMA (2000)
- The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Chen, P.L., Chen, C.F., Chen, Y., Xiao, J., Sharp, Z.D., Lee, W.H. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Mutation analysis in the BRCA2 gene in primary breast cancers. Miki, Y., Katagiri, T., Kasumi, F., Yoshimoto, T., Nakamura, Y. Nat. Genet. (1996)
- A novel ubiquitin ligase is deficient in Fanconi anemia. Meetei, A.R., de Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., van de Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E., Hoatlin, M.E., Joenje, H., Wang, W. Nat. Genet. (2003)
- Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Dong, Y., Hakimi, M.A., Chen, X., Kumaraswamy, E., Cooch, N.S., Godwin, A.K., Shiekhattar, R. Mol. Cell (2003)
- Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Chen, J., Silver, D.P., Walpita, D., Cantor, S.B., Gazdar, A.F., Tomlinson, G., Couch, F.J., Weber, B.L., Ashley, T., Livingston, D.M., Scully, R. Mol. Cell (1998)
- The BRCA2 gene product functionally interacts with p53 and RAD51. Marmorstein, L.Y., Ouchi, T., Aaronson, S.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. Vance, K.W., Carreira, S., Brosch, G., Goding, C.R. Cancer Res. (2005)
- Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients. Choi, D.H., Lee, M.H., Bale, A.E., Carter, D., Haffty, B.G. J. Clin. Oncol. (2004)
- BRCA2 mutations and androgen receptor expression as independent predictors of outcome of male breast cancer patients. Kwiatkowska, E., Teresiak, M., Filas, V., Karczewska, A., Breborowicz, D., Mackiewicz, A. Clin. Cancer Res. (2003)
- Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A. Mote, P.A., Leary, J.A., Avery, K.A., Sandelin, K., Chenevix-Trench, G., Kirk, J.A., Clarke, C.L. Genes Chromosomes Cancer (2004)
- Androgen pathway dysregulation in BRCA1-mutated breast tumors. Berns, E.M., Dirkzwager-Kiel, M.J., Kuenen-Boumeester, V., Timmermans, M., Verhoog, L.C., van den Ouweland, A.M., Meijer-Heijboer, H., Klijn, J.G., van der Kwast, T.H. Breast Cancer Res. Treat. (2003)
- Cellular characterization of cells from the Fanconi anemia complementation group, FA-D1/BRCA2. Godthelp, B.C., van Buul, P.P., Jaspers, N.G., Elghalbzouri-Maghrani, E., van Duijn-Goedhart, A., Arwert, F., Joenje, H., Zdzienicka, M.Z. Mutat. Res. (2006)
- Novel germline mutations in breast cancer susceptibility genes BRCA1, BRCA2 and p53 gene in breast cancer patients from India. Hedau, S., Jain, N., Husain, S.A., Mandal, A.K., Ray, G., Shahid, M., Kant, R., Gupta, V., Shukla, N.K., Deo, S.S., Das, B.C. Breast Cancer Res. Treat. (2004)
- Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. Shin, D.S., Pellegrini, L., Daniels, D.S., Yelent, B., Craig, L., Bates, D., Yu, D.S., Shivji, M.K., Hitomi, C., Arvai, A.S., Volkmann, N., Tsuruta, H., Blundell, T.L., Venkitaraman, A.R., Tainer, J.A. EMBO J. (2003)
- Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1. Hussain, S., Witt, E., Huber, P.A., Medhurst, A.L., Ashworth, A., Mathew, C.G. Hum. Mol. Genet. (2003)
- Oncogenic pathways in hereditary and sporadic breast cancer. Kenemans, P., Verstraeten, R.A., Verheijen, R.H. Maturitas. (2004)
- BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Schoenfeld, A.R., Apgar, S., Dolios, G., Wang, R., Aaronson, S.A. Mol. Cell. Biol. (2004)
- The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA. Thorslund, T., McIlwraith, M.J., Compton, S.A., Lekomtsev, S., Petronczki, M., Griffith, J.D., West, S.C. Nat. Struct. Mol. Biol. (2010)
- Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1. Futamura, M., Arakawa, H., Matsuda, K., Katagiri, T., Saji, S., Miki, Y., Nakamura, Y. Cancer Res. (2000)
- The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair. Lu, H., Guo, X., Meng, X., Liu, J., Allen, C., Wray, J., Nickoloff, J.A., Shen, Z. Mol. Cell. Biol. (2005)
- Inactivation of BRCA1 and BRCA2 in ovarian cancer. Hilton, J.L., Geisler, J.P., Rathe, J.A., Hattermann-Zogg, M.A., DeYoung, B., Buller, R.E. J. Natl. Cancer Inst. (2002)
- BRCA2 and Smad3 synergize in regulation of gene transcription. Preobrazhenska, O., Yakymovych, M., Kanamoto, T., Yakymovych, I., Stoika, R., Heldin, C.H., Souchelnytskyi, S. Oncogene (2002)
- BRCA2-dependent and independent formation of RAD51 nuclear foci. Tarsounas, M., Davies, D., West, S.C. Oncogene (2003)
- p53 mediates repression of the BRCA2 promoter and down-regulation of BRCA2 mRNA and protein levels in response to DNA damage. Wu, K., Jiang, S.W., Couch, F.J. J. Biol. Chem. (2003)
- Poly(ADP-ribose) polymerase-1 down-regulates BRCA2 expression through the BRCA2 promoter. Wang, J., Bian, C., Li, J., Couch, F.J., Wu, K., Zhao, R.C. J. Biol. Chem. (2008)
- Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Yamamoto, K., Ishiai, M., Matsushita, N., Arakawa, H., Lamerdin, J.E., Buerstedde, J.M., Tanimoto, M., Harada, M., Thompson, L.H., Takata, M. Mol. Cell. Biol. (2003)
- Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers. Palacios, J., Honrado, E., Osorio, A., Cazorla, A., Sarrió, D., Barroso, A., Rodríguez, S., Cigudosa, J.C., Diez, O., Alonso, C., Lerma, E., Sánchez, L., Rivas, C., Benítez, J. Clin. Cancer Res. (2003)
- Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. Buchholz, T.A., Wu, X., Hussain, A., Tucker, S.L., Mills, G.B., Haffty, B., Bergh, S., Story, M., Geara, F.B., Brock, W.A. Int. J. Cancer (2002)
- Breast cancer after mantle irradiation for Hodgkin's disease: correlation of clinical, pathologic, and molecular features including loss of heterozygosity at BRCA1 and BRCA2. Gaffney, D.K., Hemmersmeier, J., Holden, J., Marshall, J., Smith, L.M., Avizonis, V., Tran, T., Neuhausen, S.L. Int. J. Radiat. Oncol. Biol. Phys. (2001)
- Age-dependent morphological alterations of human ovaries from populations with and without BRCA mutations. Qi Cai, K., Klein-Szanto, A., Karthik, D., Edelson, M., Daly, M.B., Ozols, R.F., Lynch, H.T., Godwin, A.K., Xu, X.X. Gynecol. Oncol. (2006)