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Mouse models to study G-protein-mediated signaling.

The G-protein-mediated signaling system has evolved as one of the most widely used transmembrane signaling mechanisms in eukaryotic organisms. Mammalian cells express many G-protein-coupled receptors as well as several types of heterotrimeric G-proteins and effectors. This review focuses on recent data from studies in mutant mice, which have elucidated some of the roles of G-protein-mediated signaling in physiology and pathophysiology.[1]

References

  1. Mouse models to study G-protein-mediated signaling. Wettschureck, N., Moers, A., Offermanns, S. Pharmacol. Ther. (2004) [Pubmed]
 
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