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Barry, R.J. et al.

Barry, Clarke, McCarthy, Selikowitz, Rushby, Ploskova,

EEG differences in children as a function of resting-state arousal level.

OBJECTIVE: This study aimed to explore the basis of a theoretical position which has major impact in the current literature on attention-deficit/hyperactivity disorder (AD/HD) - that the ratio of theta to beta power in the EEG (the theta/beta ratio) represents central nervous system (CNS) arousal. METHODS: Resting state topographic EEG activity was investigated as a function of CNS arousal in normal right-handed boys. Arousal was defined in terms of electrodermal activity, which has a long history in Psychology as a measure of CNS arousal. RESULTS: Relative delta, theta, and beta power, and the theta/beta ratio, failed to differ significantly between age-matched groups which differed markedly in skin conductance level and non-specific electrodermal fluctuations. The high-arousal group showed significantly lower levels of relative alpha power, particularly in posterior and hemispheric regions, with higher alpha frequencies in these areas. CONCLUSIONS: These data fail to support the theoretical linkage between the theta/beta ratio and CNS arousal. Further work is needed to disentangle the different correlates of arousal and task-related activation, particularly in cognitive and attentional-processing terms. SIGNIFICANCE: The outcomes of this study, in addition to clarifying the nature of EEG markers of CNS arousal, have important implications for our understanding of AD/HD, as they require re-evaluation of current models of the disorder.[1]

References

EEG differences in children as a function of resting-state arousal level. Barry, R.J., Clarke, A.R., McCarthy, R., Selikowitz, M., Rushby, J.A., Ploskova, E. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2004) [Pubmed]

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