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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Central Nervous System

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Disease relevance of Central Nervous System


Psychiatry related information on Central Nervous System


High impact information on Central Nervous System

  • The glutamate transporters are expressed at high levels in both glia and neurons of the central nervous system [11].
  • All four glycine transporters of the "GLYT family" also belong to the neurotransmitter superfamily and exhibit the greatest expression in the central nervous system [11].
  • Ghrelin is orexigenic; it is secreted from the stomach and circulates in the bloodstream under fasting conditions, indicating that it transmits a hunger signal from the periphery to the central nervous system [12].
  • The current working hypothesis that transient declines in blood glucose are endogenous metabolic patterns that are detected and recognized by the central nervous system and are mapped into meal initiation in rats and are correlated with meal requests in humans are then presented [13].
  • In the central nervous system, dopamine receptors are widely expressed because they are involved in the control of locomotion, cognition, emotion, and affect as well as neuroendocrine secretion [14].

Chemical compound and disease context of Central Nervous System


Biological context of Central Nervous System


Anatomical context of Central Nervous System


Associations of Central Nervous System with chemical compounds


Gene context of Central Nervous System


Analytical, diagnostic and therapeutic context of Central Nervous System

  • The frequency of anti-P was not increased in patients with other central nervous system manifestations of SLE (3 of 20, by radioimmunoassay), in patients with transient behavioral abnormalities due to SLE (none of 8), in patients with psychosis who did not have SLE (none of 13), or in normal controls (none of 20) [40].
  • We investigated whether allogeneic hematopoietic stem-cell transplantation can provide a source of leukocyte galactocerebrosidase and thereby prevent the decline of central nervous system function in patients with the disease [41].
  • Generating an active immunization to cocaine offers a means of blocking the actions of the drug by preventing it from entering the central nervous system, and should have fewer side effects than treatments based on manipulation of central neurotransmitter function [42].
  • The involvement of a particular neuronal nicotinic subunit in pharmacology and behaviour was examined using gene targeting to mutate beta 2, the most widely expressed nAChR subunit in the central nervous system [43].
  • Moreover, in situ hybridization and RNA blot analysis indicate that the 5HTlc receptor is expressed in neurons in many regions of the central nervous system and suggest that this subclass of receptor may mediate many of the central actions of serotonin [44].


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