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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.

In only four chemical steps from naturally occurring artemisinin (1), trioxane dimers 6 and 7 were prepared on a multigram scale in overall 32-44% yields. In mice, both isonicotinate N-oxide dimer 6 and isobutyric acid dimer 7 were considerably more antimalarially efficacious than clinically used sodium artesunate (2) via both oral and intravenous administration. In the transgenic adenocarcinoma of mouse prostate model, some of the trioxane dimers had potent anticancer activity.[1]

References

  1. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. Posner, G.H., McRiner, A.J., Paik, I.H., Sur, S., Borstnik, K., Xie, S., Shapiro, T.A., Alagbala, A., Foster, B. J. Med. Chem. (2004) [Pubmed]
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