Disease relevance of isonicotinic acid

• Quantitative structure-activity studies have been performed for a series of 2-substituted isonicotinic acid hydrazides by correlating electronic, steric, and lipophilic properties of the substituents with the biological activity date (MIC) from serial dilution tests with Mycobacterium tuberculosis (strain H 37 Rv) [1].
• Mutagenic effects of isonicotinic acid hydracide in Fanconi's anemia [2].
• The analysis of GC-MS showed that the katG I from M. bovis BCG directly converted INH (M(r), 137) to isonicotinamide (M(r), 122), not to isonicotinic acid (M(r), 123), in the presence or absence of H(2)O(2) [3].
• 5. Neither the uninduced MAS nor the Aroclor 1254-induced MAS had an effect on any of the compounds tested and none of the MAS affected the developmental toxicity of INA [4].

High impact information on isonicotinic acid

• Pretreatment with the acyl amidase inhibitor, bis-p-nitrophenyl phosphate, inhibited the hydrolysis of acetylisoniazid to isonicotinic acid plus acetylhydrazine and concomitantly decreased the covalent binding of acetyl-labeled acetylisoniazid [5].
• Bioactive 1,4-dihydroisonicotinic acid derivatives prevent oxidative damage of liver cells [6].
• Two novel homochiral lanthanide-silver heterometallic coordination polymers LnAg(OAc)(IN)(3) [Ln = Nd (1), Eu (2), HIN = isonicotinic acid, HOAc = acetic acid] have been prepared under hydrothermal conditions, which were characterized by elemental analysis, infrared, thermogravimetric analysis, and single-crystal X-ray diffraction [7].
• Effects of two derivatives of 1,4-dihydroisonicotinic acid (1,4-DHINA) against the monofunctional alkylating agent ethyl methanesulfonate (EMS) were studied in the micronucleus test in (CBA x C57Bl/6(j)) mice [8].
• Isoniazid was oxidized by activated leukocytes to isonicotinic acid [9].

Chemical compound and disease context of isonicotinic acid

• Catalase-peroxidase of Mycobacterium bovis BCG converts isoniazid to isonicotinamide, but not to isonicotinic acid: Differentiation parameter between enzymes of Mycobacterium bovis BCG and Mycobacterium tuberculosis [3].

Biological context of isonicotinic acid

• 3. Rapid and slow acetylation did not differ in their ability of hydrolyse acetylisoniazid to isonicotonic acid plus monoacetylhydrazine, or to conjugate isonicotinic acid with glycine [10].
• Some effects of 1,4-dihydroisonicotinic acid derivatives on repair pathways involved in chemical mutagenesis [11].
• Quantitative structure-activity relationship (QSAR) studies have been performed for a series of 2-substituted isonicotinic acid hydrazides utilizing theoretical molecular descriptors [12].
• Carbonic anhydrase inhibitors. Water-soluble, topically effective intraocular pressure lowering agents derived from isonicotinic acid and aromatic/heterocyclic sulfonamides: is the tail more important than the ring [13]?
• Among the compounds, which inhibited cell proliferation measured by MTT assay, isonicotinic acid, nicotinamide N-oxide, and nicotinamide induced NBT reducing activity [14].

Anatomical context of isonicotinic acid

• Evidence for LT release was found in five out of six patients, following stimulation of the peripheral blood lymphocytes with INH or isonicotinic acid (INA) conjugated to human serum albumin [15].
• The quaternary isonicotinic acid 2-butyne-1,4-diyl bisester (10b) displayed some functional selectivity for M2 receptors (-log EC50 = 5.78) [6- to 9-fold over M1/M4 (-log EC50/vas deferens = 5.03) and M3 receptors (-log EC50 = 4.83)] without showing nicotinic effects.(ABSTRACT TRUNCATED AT 250 WORDS)[16]
• Late Xenopus laevis blastulae were exposed to INH, AH, and INA for 96 h in two separate static-renewal tests with and without the presence of three differently induced metabolic activation systems (MAS) [4].

Associations of isonicotinic acid with other chemical compounds

• A roughened silver electrode modified with silver nanoparticles is used as a substrate, on which high-quality surface-enhanced Raman spectroscopy (SERS) of isonicotinic acid (INA) are obtained, indicating that the silver-modified silver electrode is a highly SERS-active substrate [17].
• Niacin. II: Identification of isonicotinic acid in niacin by liquid chromatography with diode array detection [18].
• Identification of a cytochrome P450 cDNA (CYP98A5) from Phaseolus vulgaris, inducible by 3,5-dichlorosalicylic acid and 2,6-dichloro isonicotinic acid [19].
• Except for the isonicotinic acid ones, these nicotinoylamino acid analogs were shown to function as substrates for both the hydrolysis and the transglycosidation reactions catalyzed by the mammalian NAD glycohydrolases, though their substrate activities were lower than those with the original pyridine nucleotides (NMN, NAD, and NADP) [20].
• The uptake was increased by the imposition of an inside-positive membrane potential and was significantly inhibited by monocarboxylic acids such as benzoic acid, salicylic acid, acetic acid, propionic acid, valproic acid and L-lactic acids as well as two isomers (isonicotinic acid and picolinic acid) [21].

Gene context of isonicotinic acid

• Renin inhibitors containing nicotinic or isonicotinic acid at the N-terminus. Part V [22].
• We present an ab initio molecular dynamics study of the complex between acyl carrier protein reductase InhA from M. tuberculosis and isonicotinic acid hydrazide-NADH [23].

Analytical, diagnostic and therapeutic context of isonicotinic acid

• Two-dimensional gel electrophoresis and immunoblot analyses indicated that two of the prominent isonicotinic acid hydrazide-inducible polypeptides were members of the antigen 85 complex, recently demonstrated to have mycolyltransferase activity [24].
• In the present study, a conjugatable, highly luminescent Re(I) metal-ligand complex, [Re(bcp)(CO)3(4-COOHPy)](ClO4), where bcp is 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline and 4-COOHPy is isonicotinic acid, has been evaluated for use in fluorescence polarization immunoassays (FPIs) with high-molecular-weight antigens [25].
• Furthermore, IgE antibodies specific to INH and isonicotinic acid (INA), the major metabolite of INH, were examined by means of enzyme-linked immunosorbent assay (ELISA) [26].

References