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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Fhit is a physiological target of the protein kinase Src.

The FHIT gene is a tumor suppressor that is frequently inactivated by genomic alterations at chromosomal region 3p14. 2. In the last few years, a considerable amount of data describing inactivation of FHIT in a variety of human malignancies and demonstrating the tumor suppressor potential of Fhit have been reported. Despite the demonstration that FHIT functions as a tumor suppressor, the pathway through which Fhit induces apoptosis and inhibits growth of cancer cells is not known. Our data demonstrate that Fhit is a target of tyrosine phosphorylation by the Src protein kinase. We show that Src phosphorylates Y114 of Fhit in vitro and in vivo, providing insight into a biochemical pathway involved in Fhit signaling.[1]

References

  1. Fhit is a physiological target of the protein kinase Src. Pekarsky, Y., Garrison, P.N., Palamarchuk, A., Zanesi, N., Aqeilan, R.I., Huebner, K., Barnes, L.D., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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