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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Transactivation by AP-1 is a molecular target of T cell clonal anergy.

Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.[1]


  1. Transactivation by AP-1 is a molecular target of T cell clonal anergy. Kang, S.M., Beverly, B., Tran, A.C., Brorson, K., Schwartz, R.H., Lenardo, M.J. Science (1992) [Pubmed]
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