Gene Review:
Il2 - interleukin 2
Mus musculus
Synonyms:
IL-2, Il-2, Interleukin-2, T-cell growth factor, TCGF
- Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes. Rapp, U.R., Cleveland, J.L., Brightman, K., Scott, A., Ihle, J.N. Nature (1985)
- Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Lenardo, M.J. Nature (1991)
- Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Kondo, M., Takeshita, T., Higuchi, M., Nakamura, M., Sudo, T., Nishikawa, S., Sugamura, K. Science (1994)
- Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection. Karupiah, G., Blanden, R.V., Ramshaw, I.A. J. Exp. Med. (1990)
- Multiple lymphokine production by a phorbol ester-stimulated mouse thymoma: relationship to cell cycle events. Pearlstein, K.T., Staiano-Coico, L., Miller, R.A., Pelus, L.M., Kirch, M.E., Stutman, O., Palladino, M.A. J. Natl. Cancer Inst. (1983)
- Interleukin-2 activates the gamma-interferon gene in newborn mice. Lipoldová, M., Holán, V. Immunol. Cell. Biol. (1991)
- Influence of acute and repeated interleukin-2 administration on spatial learning, locomotor activity, exploratory behaviors, and anxiety. Lacosta, S., Merali, Z., Anisman, H. Behav. Neurosci. (1999)
- Anti-TNF-alpha antibody normalizes serum leptin in IL-2 deficient mice. Gaetke, L.M., Oz, H.S., Frederich, R.C., McClain, C.J. Journal of the American College of Nutrition. (2003)
- Different effects of IL-2 in vivo treatment and emotional stress on POMC gene expression in the pituitary of mice. Chesnokova, V., Busick, J., Chesnokov, V., Jakobson, G., Ivanova, L. Horm. Metab. Res. (1997)
- Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice. Sudom, K., Turrin, N.P., Hayley, S., Anisman, H. Neuroimmunomodulation (2004)
- Treatment of mice bearing BCL1 lymphoma with bispecific antibodies. Brissinck, J., Demanet, C., Moser, M., Leo, O., Thielemans, K. J. Immunol. (1991)
- Differential regulation of murine T lymphocyte subsets. Fitch, F.W., McKisic, M.D., Lancki, D.W., Gajewski, T.F. Annu. Rev. Immunol. (1993)
- Roles of alpha beta and gamma delta T cell subsets in viral immunity. Doherty, P.C., Allan, W., Eichelberger, M., Carding, S.R. Annu. Rev. Immunol. (1992)
- QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. Encinas, J.A., Wicker, L.S., Peterson, L.B., Mukasa, A., Teuscher, C., Sobel, R., Weiner, H.L., Seidman, C.E., Seidman, J.G., Kuchroo, V.K. Nat. Genet. (1999)
- IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations. Krulová, M., Havelková, H., Kosarová, M., Holán, V., Hart, A.A., Demant, P., Lipoldová, M. Genomics. (1997)
- Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility. Lipoldová, M., Havelková, H., Badalová, J., Demant, P. Int. J. Cancer. (2005)
- Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. Tripodis, N., Hart, A.A., Fijneman, R.J., Demant, P. J. Natl. Cancer. Inst. (2001)
- Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis. Otto, J.M., Cs-Szabó, G., Gallagher, J., Velins, S., Mikecz, K., Buzás, E.I., Enders, J.T., Li, Y., Olsen, B.R., Glant, T.T. Arthritis. Rheum. (1999)
- Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Miyazaki, T., Liu, Z.J., Kawahara, A., Minami, Y., Yamada, K., Tsujimoto, Y., Barsoumian, E.L., Permutter, R.M., Taniguchi, T. Cell (1995)
- Gene therapy of metastatic cancer by in vivo retroviral gene targeting. Hurford, R.K., Dranoff, G., Mulligan, R.C., Tepper, R.I. Nat. Genet. (1995)
- T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells. Loughnan, M.S., Takatsu, K., Harada, N., Nossal, G.J. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Bacillus Calmette-Guérin plus interleukin-2 and/or granulocyte/macrophage-colony-stimulating factor enhances immunocompetent cell production of interferon-gamma, which inhibits B16F10 melanoma cell growth in vitro. Fujimoto, T., O'Donnell, M.A., Szilvasi, A., Yang, H., Duda, R.B. Cancer Immunol. Immunother. (1996)
- Evaluation of combined vaccinia virus-mediated antitumor gene therapy with p53, IL-2, and IL-12 in a glioma model. Chen, B., Timiryasova, T.M., Andres, M.L., Kajioka, E.H., Dutta-Roy, R., Gridley, D.S., Fodor, I. Cancer Gene Ther. (2000)
- Comparison of phage pVIII and KLH as vector in inducing the production of cytokines in C57BL/6J mice. Su, Q.P., Wen, D.Z., Yang, Q., Zhang, Y.H., Liu, C., Wang, L. Vaccine (2007)
- Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2. Mocchegiani, E., Perissin, L., Santarelli, L., Tibaldi, A., Zorzet, S., Rapozzi, V., Giacconi, R., Bulian, D., Giraldi, T. Int. J. Immunopharmacol. (1999)
- Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3. Teuscher, C., Wardell, B.B., Lunceford, J.K., Michael, S.D., Tung, K.S. J. Exp. Med. (1996)
- Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Lyons, P.A., Armitage, N., Argentina, F., Denny, P., Hill, N.J., Lord, C.J., Wilusz, M.B., Peterson, L.B., Wicker, L.S., Todd, J.A. Genome Res. (2000)
- p300/Cyclic AMP-responsive element binding-binding protein mediates transcriptional coactivation by the CD28 T cell costimulatory receptor. Nandiwada, S.L., Li, W., Zhang, R., Mueller, D.L. J. Immunol. (2006)
- Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene. Denny, P., Lord, C.J., Hill, N.J., Goy, J.V., Levy, E.R., Podolin, P.L., Peterson, L.B., Wicker, L.S., Todd, J.A., Lyons, P.A. Diabetes (1997)
- A function for interleukin 2 in Foxp3-expressing regulatory T cells. Fontenot, J.D., Rasmussen, J.P., Gavin, M.A., Rudensky, A.Y. Nat. Immunol. (2005)
- Selective growth of natural cytotoxic but not natural killer effector cells in interleukin-3. Djeu, J.Y., Lanza, E., Pastore, S., Hapel, A.J. Nature (1983)
- Unique structure of murine interleukin-2 as deduced from cloned cDNAs. Kashima, N., Nishi-Takaoka, C., Fujita, T., Taki, S., Yamada, G., Hamuro, J., Taniguchi, T. Nature (1985)
- Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. D'Cruz, L.M., Klein, L. Nat. Immunol. (2005)
- Interleukin 2-induced proliferation of murine natural killer cells in vivo. Biron, C.A., Young, H.A., Kasaian, M.T. J. Exp. Med. (1990)
- Retinoids are important cofactors in T cell activation. Garbe, A., Buck, J., Hämmerling, U. J. Exp. Med. (1992)
- Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction. Kobayashi, N., Kono, T., Hatakeyama, M., Minami, Y., Miyazaki, T., Perlmutter, R.M., Taniguchi, T. Proc. Natl. Acad. Sci. U.S.A. (1993)
- B-cell growth factor: distinction from T-cell growth factor and B-cell maturation factor. Leanderson, T., Lundgren, E., Ruuth, E., Borg, H., Persson, H., Coutinho, A. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Receptor antagonist and selective agonist derivatives of mouse interleukin-2. Zurawski, S.M., Zurawski, G. EMBO J. (1992)
- Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene. Lécine, P., Algarté, M., Rameil, P., Beadling, C., Bucher, P., Nabholz, M., Imbert, J. Mol. Cell. Biol. (1996)
- Interleukin 1 augments the expression of the interleukin 2 receptor alpha-chain in interleukin 6-stimulated myeloid cells by a transcriptional and posttranscriptional mechanism. Ruhl, S., Schwabe, M., Pluznik, D.H. Exp. Hematol. (1992)
- Interleukin 2-mediated uncoupling of T cell receptor alpha/beta from CD3 signaling. Haughn, L., Leung, B., Boise, L., Veillette, A., Thompson, C., Julius, M. J. Exp. Med. (1998)
- The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals. Chen, M., Cheng, A., Chen, Y.Q., Hymel, A., Hanson, E.P., Kimmel, L., Minami, Y., Taniguchi, T., Changelian, P.S., O'Shea, J.J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation. Ravichandran, K.S., Burakoff, S.J. J. Biol. Chem. (1994)
- The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses. Tarrant, J.M., Groom, J., Metcalf, D., Li, R., Borobokas, B., Wright, M.D., Tarlinton, D., Robb, L. Mol. Cell. Biol. (2002)
- Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. McCaffrey, P.G., Luo, C., Kerppola, T.K., Jain, J., Badalian, T.M., Ho, A.M., Burgeon, E., Lane, W.S., Lambert, J.N., Curran, T. Science (1993)
- Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. Rapoport, M.J., Jaramillo, A., Zipris, D., Lazarus, A.H., Serreze, D.V., Leiter, E.H., Cyopick, P., Danska, J.S., Delovitch, T.L. J. Exp. Med. (1993)
- Differential regulation of interleukin 4 and interleukin 5 gene expression: a comparison of T-cell gene induction by anti-CD3 antibody or by exogenous lymphokines. Bohjanen, P.R., Okajima, M., Hodes, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990)
- Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia. Okamoto, M., Kato, S., Oizumi, K., Kinoshita, M., Inoue, Y., Hoshino, K., Akira, S., McKenzie, A.N., Young, H.A., Hoshino, T. Blood (2002)
- Stem cell factor enhances interleukin-2-mediated expansion of murine natural killer cells in vivo. Fehniger, T.A., Carson, W.E., Mrózek, E., Caligiuri, M.A. Blood (1997)
- A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms. Zheng, L., Sharma, R., Gaskin, F., Fu, S.M., Ju, S.T. J. Immunol. (2007)
- Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor. Widmer, M.B., Grabstein, K.H. Nature (1987)
- IL-15 and IL-2: a matter of life and death for T cells in vivo. Li, X.C., Demirci, G., Ferrari-Lacraz, S., Groves, C., Coyle, A., Malek, T.R., Strom, T.B. Nat. Med. (2001)
- Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Thomis, D.C., Gurniak, C.B., Tivol, E., Sharpe, A.H., Berg, L.J. Science (1995)
- Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Hodge, M.R., Ranger, A.M., Charles de la Brousse, F., Hoey, T., Grusby, M.J., Glimcher, L.H. Immunity (1996)
- An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Nakajima, H., Liu, X.W., Wynshaw-Boris, A., Rosenthal, L.A., Imada, K., Finbloom, D.S., Hennighausen, L., Leonard, W.J. Immunity (1997)
- Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. Dallman, M.J., Larsen, C.P., Morris, P.J. J. Exp. Med. (1991)
- Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the immunologically privileged central nervous system. Sampson, J.H., Archer, G.E., Ashley, D.M., Fuchs, H.E., Hale, L.P., Dranoff, G., Bigner, D.D. Proc. Natl. Acad. Sci. U.S.A. (1996)