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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Variant MYST4-CBP gene fusion in a t(10;16) acute myeloid leukaemia.

We report a novel fusion of the MYST4 and CBP genes in an acute myeloid leukaemia (AML)-M4 patient exhibiting t(10;16)(q22;p13) and t(11;17)(q23;q21). The t(10;16)(q22;p13) resulted in a rearrangement, where MYST4-CBP and CBP-MYST4 chimaeric transcripts were products of in-frame fusions of MYST4 exon 17 to CBP exon 6 and CBP exon 4 to MYST4 exon 18 respectively. The potential resulting chimaeric proteins showed similarities with MYST3- CBP, MYST3-P300 and MYST3-NCOA2 putative fusion proteins found in other cases of AML.[1]

References

  1. Variant MYST4-CBP gene fusion in a t(10;16) acute myeloid leukaemia. Murati, A., Adélaïde, J., Mozziconacci, M.J., Popovici, C., Carbuccia, N., Letessier, A., Birg, F., Birnbaum, D., Chaffanet, M. Br. J. Haematol. (2004) [Pubmed]
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