The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Gene Fusion

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gene Fusion


High impact information on Gene Fusion

  • Moreover, ETV6-NTRK3 gene fusions provide a potential diagnostic marker for CFS [6].
  • A sax-3::GFP fusion gene is expressed in developing neurons during axon outgrowth, and sax-3 function is required at the time of axon guidance, suggesting that this gene mediates cell interactions during guidance decisions [7].
  • These gene fusions delete exon 1 of PDGFB, and release this growth factor from its normal regulation [8].
  • In more than 99% of cases, this disruption results in the formation of a PML-RARA gene fusion [9].
  • AP3 and PI also activate an AP3 promoter-reporter gene fusion, demonstrating that AP3 positively autoregulates [10].

Chemical compound and disease context of Gene Fusion


Biological context of Gene Fusion


Anatomical context of Gene Fusion

  • We studied the in vivo expression of this MT-hHPRT fusion gene and observed preferential hHPRT expression in tissues of the central nervous system (CNS) [20].
  • Here, we employ RAG2-green fluorescent protein (GFP) fusion gene knock-in mice to show that RAG(+) B lineage cells do appear in the spleen after the administration of alum alone, and that their appearance is independent of T cell interactions via the CD40 pathway [21].
  • We recently showed that a nerve growth factor-human growth hormone (NGF-hGH) fusion gene containing the promoter and 750 bp of 5' flanking region is transcriptionally active in the NGF-secreting L929 mouse fibroblast cell line [22].
  • To explore the function of IGF-I on SMC in vivo, the mouse SMC alpha-actin promoter fragment SMP8 (-1074 bp, 63 bp of 5'UT and 2.5 kb of intron 1) was cloned upstream of rat IGF-I cDNA, and the fusion gene microinjected to fertilized eggs of the FVB-N mouse strain [23].
  • We have studied the role of the Mll-AF9 gene fusion made in mouse embryonic stem cells by an homologous recombination knock-in [24].

Associations of Gene Fusion with chemical compounds

  • Thymidine kinase activity is regulated by cadmium when this fusion gene is transfected into mouse tk- L cells [25].
  • Here, we show that two tandemly linked GRE/PREs conferred progesterone inducibility synergistically to a heterologous TK-CAT fusion gene [26].
  • Using the BamC promoter driving a hygromycin-thymidine kinase fusion gene or controls, we demonstrated that sensitivity to ganciclovir was selectively enhanced in cells expressing EBNA2 [27].
  • Here we report that cAMP analogues and activators of adenylate cyclase regulate a proenkephalin-chloramphenicol acetyl transferase fusion gene when transiently expressed in tissue culture cells [28].
  • We showed previously that the transcript from an actin-HIS4 gene fusion containing the mutation TACTAAC to TACTACC (designated C259) is spliced inefficiently, thereby preventing growth on the histidine precursor histidinol [29].

Gene context of Gene Fusion

  • An assay has been developed to measure the functional activity of different forms of PRL receptor by cotransfecting a milk protein fusion gene specific to PRL coupled to a reporter-gene along with the cDNA of the PRL receptor [30].
  • To distinguish whether these factors bound to UAS2 cooperatively or formed a complex in the absence of DNA, HAP2 and HAP3 were tagged by gene fusion to LexA and beta-galactosidase, respectively, and purified through four chromatographic steps [31].
  • Using a combination of gene fusion analysis and pulse-chase experiments, we demonstrate that the hfq mutant is specifically impaired in rpoS translation [32].
  • Using Ddc-lacZ gene fusions, we show that these mutations affect Ddc expression in the embryo [33].
  • Expression of an unc-51/lacZ fusion gene was observed in many neurons at all stages [34].

Analytical, diagnostic and therapeutic context of Gene Fusion


  1. An E. coli aminoacyl-tRNA synthetase can substitute for yeast mitochondrial enzyme function in vivo. Edwards, H., Schimmel, P. Cell (1987) [Pubmed]
  2. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. Kawai, A., Woodruff, J., Healey, J.H., Brennan, M.F., Antonescu, C.R., Ladanyi, M. N. Engl. J. Med. (1998) [Pubmed]
  3. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Corral, J., Lavenir, I., Impey, H., Warren, A.J., Forster, A., Larson, T.A., Bell, S., McKenzie, A.N., King, G., Rabbitts, T.H. Cell (1996) [Pubmed]
  4. A universal influenza A vaccine based on the extracellular domain of the M2 protein. Neirynck, S., Deroo, T., Saelens, X., Vanlandschoot, P., Jou, W.M., Fiers, W. Nat. Med. (1999) [Pubmed]
  5. Polyadenylation of the Xenopus beta 1 globin mRNA at a downstream minor site in the absence of the major site and utilization of an AAUACA polyadenylation signal. Mason, P.J., Jones, M.B., Elkington, J.A., Williams, J.G. EMBO J. (1985) [Pubmed]
  6. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Knezevich, S.R., McFadden, D.E., Tao, W., Lim, J.F., Sorensen, P.H. Nat. Genet. (1998) [Pubmed]
  7. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans. Zallen, J.A., Yi, B.A., Bargmann, C.I. Cell (1998) [Pubmed]
  8. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Simon, M.P., Pedeutour, F., Sirvent, N., Grosgeorge, J., Minoletti, F., Coindre, J.M., Terrier-Lacombe, M.J., Mandahl, N., Craver, R.D., Blin, N., Sozzi, G., Turc-Carel, C., O'Brien, K.P., Kedra, D., Fransson, I., Guilbaud, C., Dumanski, J.P. Nat. Genet. (1997) [Pubmed]
  9. Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Wells, R.A., Catzavelos, C., Kamel-Reid, S. Nat. Genet. (1997) [Pubmed]
  10. Arabidopsis homeotic gene APETALA3 ectopic expression: transcriptional and posttranscriptional regulation determine floral organ identity. Jack, T., Fox, G.L., Meyerowitz, E.M. Cell (1994) [Pubmed]
  11. In vivo DNA cloning and adjacent gene fusing with a mini-Mu-lac bacteriophage containing a plasmid replicon. Groisman, E.A., Castilho, B.A., Casadaban, M.J. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  12. Introduction of asymmetry in the naturally symmetric restriction endonuclease EcoRV to investigate intersubunit communication in the homodimeric protein. Stahl, F., Wende, W., Jeltsch, A., Pingoud, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. The mtr locus is a two-gene operon required for transcription attenuation in the trp operon of Bacillus subtilis. Gollnick, P., Ishino, S., Kuroda, M.I., Henner, D.J., Yanofsky, C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  14. Isolation of gene fusions (soi::lacZ) inducible by oxidative stress in Escherichia coli. Kogoma, T., Farr, S.B., Joyce, K.M., Natvig, D.O. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  15. Antitermination of E. coli rRNA transcription is caused by a control region segment containing lambda nut-like sequences. Li, S.C., Squires, C.L., Squires, C. Cell (1984) [Pubmed]
  16. Functional domains of the human glucocorticoid receptor. Giguère, V., Hollenberg, S.M., Rosenfeld, M.G., Evans, R.M. Cell (1986) [Pubmed]
  17. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype. Ingraham, H.A., Chen, R.P., Mangalam, H.J., Elsholtz, H.P., Flynn, S.E., Lin, C.R., Simmons, D.M., Swanson, L., Rosenfeld, M.G. Cell (1988) [Pubmed]
  18. Human Hox-4.2 and Drosophila deformed encode similar regulatory specificities in Drosophila embryos and larvae. McGinnis, N., Kuziora, M.A., McGinnis, W. Cell (1990) [Pubmed]
  19. Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing. Fouser, L.A., Friesen, J.D. Cell (1986) [Pubmed]
  20. Expression of human HPRT in the central nervous system of transgenic mice. Stout, J.T., Chen, H.Y., Brennand, J., Caskey, C.T., Brinster, R.L. Nature (1985) [Pubmed]
  21. Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. Gärtner, F., Alt, F.W., Monroe, R.J., Seidl, K.J. J. Exp. Med. (2000) [Pubmed]
  22. Cell-specific and developmental regulation of a nerve growth factor-human growth hormone fusion gene in transgenic mice. Alexander, J.M., Hsu, D., Penchuk, L., Heinrich, G. Neuron (1989) [Pubmed]
  23. Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice. Wang, J., Niu, W., Nikiforov, Y., Naito, S., Chernausek, S., Witte, D., LeRoith, D., Strauch, A., Fagin, J.A. J. Clin. Invest. (1997) [Pubmed]
  24. The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis. Dobson, C.L., Warren, A.J., Pannell, R., Forster, A., Lavenir, I., Corral, J., Smith, A.J., Rabbitts, T.H. EMBO J. (1999) [Pubmed]
  25. The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells. Mayo, K.E., Warren, R., Palmiter, R.D. Cell (1982) [Pubmed]
  26. Cooperative binding of steroid hormone receptors contributes to transcriptional synergism at target enhancer elements. Tsai, S.Y., Tsai, M.J., O'Malley, B.W. Cell (1989) [Pubmed]
  27. Epstein-Barr virus-driven gene therapy for EBV-related lymphomas. Franken, M., Estabrooks, A., Cavacini, L., Sherburne, B., Wang, F., Scadden, D.T. Nat. Med. (1996) [Pubmed]
  28. A cyclic AMP- and phorbol ester-inducible DNA element. Comb, M., Birnberg, N.C., Seasholtz, A., Herbert, E., Goodman, H.M. Nature (1986) [Pubmed]
  29. A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. Couto, J.R., Tamm, J., Parker, R., Guthrie, C. Genes Dev. (1987) [Pubmed]
  30. The prolactin/growth hormone receptor family. Kelly, P.A., Djiane, J., Postel-Vinay, M.C., Edery, M. Endocr. Rev. (1991) [Pubmed]
  31. Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. Hahn, S., Guarente, L. Science (1988) [Pubmed]
  32. The RNA-binding protein HF-I, known as a host factor for phage Qbeta RNA replication, is essential for rpoS translation in Escherichia coli. Muffler, A., Fischer, D., Hengge-Aronis, R. Genes Dev. (1996) [Pubmed]
  33. Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila. Bray, S.J., Kafatos, F.C. Genes Dev. (1991) [Pubmed]
  34. Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase. Ogura, K., Wicky, C., Magnenat, L., Tobler, H., Mori, I., Müller, F., Ohshima, Y. Genes Dev. (1994) [Pubmed]
  35. Spatial and temporal expression of the period gene in Drosophila melanogaster. Liu, X., Lorenz, L., Yu, Q.N., Hall, J.C., Rosbash, M. Genes Dev. (1988) [Pubmed]
  36. Prenatal origin of acute lymphoblastic leukaemia in children. Wiemels, J.L., Cazzaniga, G., Daniotti, M., Eden, O.B., Addison, G.M., Masera, G., Saha, V., Biondi, A., Greaves, M.F. Lancet (1999) [Pubmed]
  37. Early detection of relapse by prospective reverse transcriptase-polymerase chain reaction analysis of the PML/RARalpha fusion gene in patients with acute promyelocytic leukemia enrolled in the GIMEMA-AIEOP multicenter "AIDA" trial. GIMEMA-AIEOP Multicenter "AIDA" Trial. Diverio, D., Rossi, V., Avvisati, G., De Santis, S., Pistilli, A., Pane, F., Saglio, G., Martinelli, G., Petti, M.C., Santoro, A., Pelicci, P.G., Mandelli, F., Biondi, A., Lo Coco, F. Blood (1998) [Pubmed]
  38. The kinetics and extent of engraftment of chronic myelogenous leukemia cells in non-obese diabetic/severe combined immunodeficiency mice reflect the phase of the donor's disease: an in vivo model of chronic myelogenous leukemia biology. Dazzi, F., Capelli, D., Hasserjian, R., Cotter, F., Corbo, M., Poletti, A., Chinswangwatanakul, W., Goldman, J.M., Gordon, M.Y. Blood (1998) [Pubmed]
  39. The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia. Raynaud, S., Cave, H., Baens, M., Bastard, C., Cacheux, V., Grosgeorge, J., Guidal-Giroux, C., Guo, C., Vilmer, E., Marynen, P., Grandchamp, B. Blood (1996) [Pubmed]
WikiGenes - Universities