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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

PrPSc accumulation in myocytes from sheep incubating natural scrapie.

Because variant Creutzfeldt-Jakob disease (vCJD) in humans probably results from consumption of products contaminated with tissue from animals with bovine spongiform encephalopathy, whether infectious prion protein is present in ruminant muscles is a crucial question. Here we show that experimentally and naturally scrapie-affected sheep accumulate the prion protein PrP(Sc) in a myocyte subset. In naturally infected sheep, PrP(Sc) is detectable in muscle several months before clinical disease onset. The relative amounts of PrP(Sc) suggest a 5,000-fold lower infectivity for muscle as compared to brain.[1]


  1. PrPSc accumulation in myocytes from sheep incubating natural scrapie. Andréoletti, O., Simon, S., Lacroux, C., Morel, N., Tabouret, G., Chabert, A., Lugan, S., Corbière, F., Ferré, P., Foucras, G., Laude, H., Eychenne, F., Grassi, J., Schelcher, F. Nat. Med. (2004) [Pubmed]
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