The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

GHB ameliorates naloxone-induced conditioned place aversion and physical aspects of morphine withdrawal in mice.

RATIONALE: Gamma-hydroxybutyric acid (GHB) is a naturally occurring substance in the brain, the administration of which has proved useful in the treatment of the opiate withdrawal symptoms in humans. OBJECTIVES: The aim of the present work was to validate this beneficial effect on the physical and motivational aspects of morphine withdrawal in mice. METHODS: In a first experiment, animals rendered morphine-dependent were conditioned to develop a place aversion ( CPA) to the compartment paired with naloxone administration in a two-chamber apparatus. The conditioning phase consisted of three pairings of either naloxone (0.250 mg/kg) or vehicle in one compartment, both with similar time allotments during the preconditioning test. During the testing phase, mice were again allowed to explore the entire apparatus. GHB (6, 12.5, 25, and 50 mg/kg) was administered during either the acquisition or expression phase of this conditioning. In a second experiment, the capacity of GHB to ameliorate the intensity of physical signs of morphine withdrawal was evaluated. RESULTS: GHB blocked CPA in both phases: administered during acquisition (from 12.5 mg/kg and higher) as well as in the expression phase (from 6 mg/kg, except for 25 mg/kg). It also decreased the intensity of physical signs of morphine withdrawal to near control levels measured by the modified Gellert-Holtzman scale (25 mg/kg and higher). Decreases in jumping, body shakes, and paw tremor were also observed. CONCLUSIONS: Our results support the idea that GHB ameliorates both aspects of morphine withdrawal, physical as well as motivational signs.[1]

References

  1. GHB ameliorates naloxone-induced conditioned place aversion and physical aspects of morphine withdrawal in mice. Maldonado, C., Rodríguez-Arias, M., Aguilar, M.A., Miñarro, J. Psychopharmacology (Berl.) (2004) [Pubmed]
 
WikiGenes - Universities