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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mpdz is a quantitative trait gene for drug withdrawal seizures.

Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.[1]


  1. Mpdz is a quantitative trait gene for drug withdrawal seizures. Shirley, R.L., Walter, N.A., Reilly, M.T., Fehr, C., Buck, K.J. Nat. Neurosci. (2004) [Pubmed]
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