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MeSH Review

Substance-Related Disorders

 
 
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Disease relevance of Substance-Related Disorders

 

Psychiatry related information on Substance-Related Disorders

 

High impact information on Substance-Related Disorders

  • We conclude that the Oprd1-encoded receptor, which has been proposed to be a promising target for the clinical management of pain, should also be considered in the treatment of drug addiction and other mood-related disorders [11].
  • Substance abuse, particularly cocaine use, is a significant correlate of violent injuries [12].
  • Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress, and has been implicated in the stress-like and other aversive consequences of drug abuse, such as withdrawal from alcohol [13].
  • Although neurons in this area respond to rewards on a subsecond timescale, neurochemical studies have only addressed the role of dopamine in drug addiction by examining changes in the tonic (minute-to-minute) levels of extracellular dopamine [14].
  • We conclude that substance P has an important and specific role in mediating the motivational aspects of opiates and may represent a new pharmacological route for the control of drug abuse [15].
 

Chemical compound and disease context of Substance-Related Disorders

 

Biological context of Substance-Related Disorders

 

Anatomical context of Substance-Related Disorders

 

Gene context of Substance-Related Disorders

  • Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse [31].
  • Our results reveal an unexpected complexity of ERK-dependent signaling in the brain and a critical regulatory role for ERK1 in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction [32].
  • The possibility of decreasing the behavioral and dopaminergic effects of opioids by an acute administration of GR antagonists may open new therapeutic strategies for treatment of drug addiction [33].
  • Here we show that the mouse homologues of the Drosophila Per gene, mPer1 and mPer2, modulate cocaine sensitization and reward, two phenomena extensively studied in humans and animals because of their importance for drug abuse [34].
  • These findings indicate that the natural 385A SNP in the human FAAH gene produces a mutant enzyme with reduced cellular stability, thus fortifying a potential link between functional abnormalities in the endocannabinoid system and drug abuse and dependence [35].
 

Analytical, diagnostic and therapeutic context of Substance-Related Disorders

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