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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells.

Vertebrate limb outgrowth is driven by a positive feedback loop involving Sonic Hedgehog (Shh), Gremlin, and Fgf4. By overexpressing individual components of the loop at a time after these genes are normally down-regulated in chicken embryos, we found that Shh no longer maintains Gremlin in the posterior limb. Shh- expressing cells and their descendants cannot express Gremlin. The proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells, which breaks down the Shh-Fgf4 loop and thereby affects limb size and provides a mechanism explaining regulative properties of the limb bud.[1]

References

  1. The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Scherz, P.J., Harfe, B.D., McMahon, A.P., Tabin, C.J. Science (2004) [Pubmed]
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