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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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 Hsu,  Lin,  
 

Biocompatibility and biostability of a series of poly(carbonate)urethanes.

In this work, we synthesized several MDI-based poly(carbonate)urethanes (PCU) by using four different soft segments, including two aliphatic macrodiols (poly(hexyl, ethyl)carbonate diols, MW 2017 and 865, respectively) and two aromatic macrodiols (MW approximately 2000 and 1000, respectively), in different molar ratios to MDI. We demonstrate that these polymers exhibited various degree of micro-phase separation that further influenced their surface protein adsorption, platelet activation as well as cellular attachment and growth. Polyurethanes based on poly(hexyl, ethyl)carbonate diol with MW 2017 in a molar ratio MDI/macrodiol/chain extender of either 3/2/1 or 4/3/1 resulted in greater micro-phase separation as well as superior biocompatibility and biostability.[1]

References

  1. Biocompatibility and biostability of a series of poly(carbonate)urethanes. Hsu, S.H., Lin, Z.C. Colloids and surfaces. B, Biointerfaces. (2004) [Pubmed]
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