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MeSH Review

Platelet Activation

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Disease relevance of Platelet Activation


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Chemical compound and disease context of Platelet Activation


Biological context of Platelet Activation


Anatomical context of Platelet Activation


Associations of Platelet Activation with chemical compounds


Gene context of Platelet Activation


Analytical, diagnostic and therapeutic context of Platelet Activation


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  2. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. Christman, B.W., McPherson, C.D., Newman, J.H., King, G.A., Bernard, G.R., Groves, B.M., Loyd, J.E. N. Engl. J. Med. (1992) [Pubmed]
  3. Randomised controlled trial of ketanserin and aspirin in prevention of pre-eclampsia. Steyn, D.W., Odendaal, H.J. Lancet (1997) [Pubmed]
  4. Combined administration of aspirin and a specific thrombin inhibitor in man. Clarke, R.J., Mayo, G., FitzGerald, G.A., Fitzgerald, D.J. Circulation (1991) [Pubmed]
  5. Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator. Kerins, D.M., Roy, L., FitzGerald, G.A., Fitzgerald, D.J. Circulation (1989) [Pubmed]
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  7. Nicotine effects on eicosanoid formation and hemostatic function: comparison of transdermal nicotine and cigarette smoking. Benowitz, N.L., Fitzgerald, G.A., Wilson, M., Zhang, Q. J. Am. Coll. Cardiol. (1993) [Pubmed]
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  9. Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia. Clarke, R., Harrison, G., Richards, S. J. Intern. Med. (2003) [Pubmed]
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  12. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Vu, T.K., Hung, D.T., Wheaton, V.I., Coughlin, S.R. Cell (1991) [Pubmed]
  13. Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. McFadden, E.P., Clarke, J.G., Davies, G.J., Kaski, J.C., Haider, A.W., Maseri, A. N. Engl. J. Med. (1991) [Pubmed]
  14. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. FitzGerald, G.A., Smith, B., Pedersen, A.K., Brash, A.R. N. Engl. J. Med. (1984) [Pubmed]
  15. Acute myocardial ischemia: role of atherosclerosis, thrombosis, platelet activation, coronary vasospasm, and altered arachidonic acid metabolism. Conti, C.R., Mehta, J.L. Circulation (1987) [Pubmed]
  16. Fibrin D-dimer and beta-thromboglobulin as markers of thrombogenesis and platelet activation in atrial fibrillation. Effects of introducing ultra-low-dose warfarin and aspirin. Lip, G.Y., Lip, P.L., Zarifis, J., Watson, R.D., Bareford, D., Lowe, G.D., Beevers, D.G. Circulation (1996) [Pubmed]
  17. Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated. Leo, R., Praticò, D., Iuliano, L., Pulcinelli, F.M., Ghiselli, A., Pignatelli, P., Colavita, A.R., FitzGerald, G.A., Violi, F. Circulation (1997) [Pubmed]
  18. In vivo aspirin supplementation inhibits nitric oxide consumption by human platelets. Williams, P.C., Coffey, M.J., Coles, B., Sanchez, S., Morrow, J.D., Cockcroft, J.R., Lewis, M.J., O'Donnell, V.B. Blood (2005) [Pubmed]
  19. Inhibitory effects of dipyridamole on growth, nucleoside incorporation, and platelet-activating capability in the U87MG and SKNMC human tumor cell lines. Bastida, E., del Prado, J., Almirall, L., Jamieson, G.A., Ordinas, A. Cancer Res. (1985) [Pubmed]
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  21. Directed vascular expression of the thromboxane A2 receptor results in intrauterine growth retardation. Rocca, B., Loeb, A.L., Strauss, J.F., Vezza, R., Habib, A., Li, H., FitzGerald, G.A. Nat. Med. (2000) [Pubmed]
  22. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. de Rooij, J., Zwartkruis, F.J., Verheijen, M.H., Cool, R.H., Nijman, S.M., Wittinghofer, A., Bos, J.L. Nature (1998) [Pubmed]
  23. Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptors. De Marco, L., Mazzuccato, M., Grazia Del Ben, M., Budde, U., Federici, A.B., Girolami, A., Ruggeri, Z.M. J. Clin. Invest. (1987) [Pubmed]
  24. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. Barry, O.P., Pratico, D., Lawson, J.A., FitzGerald, G.A. J. Clin. Invest. (1997) [Pubmed]
  25. The JAM family of junctional adhesion molecules. Bazzoni, G. Curr. Opin. Cell Biol. (2003) [Pubmed]
  26. The synthesis and cellular roles of phosphatidylinositol 4,5-bisphosphate. Toker, A. Curr. Opin. Cell Biol. (1998) [Pubmed]
  27. Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. Shrimpton, C.N., Borthakur, G., Larrucea, S., Cruz, M.A., Dong, J.F., López, J.A. J. Exp. Med. (2002) [Pubmed]
  28. Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets. Bertagnolli, M.E., Beckerle, M.C. J. Cell Biol. (1993) [Pubmed]
  29. Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway. Roll, R.L., Bauman, E.M., Bennett, J.S., Abrams, C.S. J. Cell Biol. (2000) [Pubmed]
  30. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Enjyoji, K., Sévigny, J., Lin, Y., Frenette, P.S., Christie, P.D., Esch, J.S., Imai, M., Edelberg, J.M., Rayburn, H., Lech, M., Beeler, D.L., Csizmadia, E., Wagner, D.D., Robson, S.C., Rosenberg, R.D. Nat. Med. (1999) [Pubmed]
  31. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. Nieswandt, B., Schulte, V., Bergmeier, W., Mokhtari-Nejad, R., Rackebrandt, K., Cazenave, J.P., Ohlmann, P., Gachet, C., Zirngibl, H. J. Exp. Med. (2001) [Pubmed]
  32. Human platelet activation by C3a and C3a des-arg. Polley, M.J., Nachman, R.L. J. Exp. Med. (1983) [Pubmed]
  33. A dual thrombin receptor system for platelet activation. Kahn, M.L., Zheng, Y.W., Huang, W., Bigornia, V., Zeng, D., Moff, S., Farese, R.V., Tam, C., Coughlin, S.R. Nature (1998) [Pubmed]
  34. Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein. Van Nostrand, W.E., Schmaier, A.H., Farrow, J.S., Cunningham, D.D. Science (1990) [Pubmed]
  35. Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2. Woulfe, D., Jiang, H., Morgans, A., Monks, R., Birnbaum, M., Brass, L.F. J. Clin. Invest. (2004) [Pubmed]
  36. Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation. Parise, L.V. Curr. Opin. Cell Biol. (1999) [Pubmed]
  37. Dietary fish oil accelerates the response to coronary thrombolysis with tissue-type plasminogen activator. Evidence for a modest platelet inhibitory effect in vivo. Braden, G.A., Knapp, H.R., Fitzgerald, D.J., FitzGerald, G.A. Circulation (1990) [Pubmed]
  38. Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase. Reilly, I.A., Doran, J.B., Smith, B., FitzGerald, G.A. Circulation (1986) [Pubmed]
  39. Time-dependent association between platelet-bound fibrinogen and the Triton X-100 insoluble cytoskeleton. Peerschke, E.I. Blood (1991) [Pubmed]
  40. Tachykinins regulate the function of platelets. Graham, G.J., Stevens, J.M., Page, N.M., Grant, A.D., Brain, S.D., Lowry, P.J., Gibbins, J.M. Blood (2004) [Pubmed]
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