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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Combined quinacrine and chlorpromazine therapy in fatal familial insomnia.

Prion diseases are invariably fatal. Recently, quinacrine and chlorpromazine have been suggested as immediate candidates for the treatment of Creutzfeldt-Jakob disease and other prion diseases. The objective of this paper was to report on 2 fatal familial insomnia patients whose overall condition worsened despite quinacrine and chlorpromazine treatment.[1]


  1. Combined quinacrine and chlorpromazine therapy in fatal familial insomnia. Benito-León, J. Clinical neuropharmacology. (2004) [Pubmed]
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