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Chemical Compound Review

Contomin     3-(2-chlorophenothiazin-10- yl)-N,N...

Synonyms: Aminazin, Fenactil, Fenaktyl, Aminazine, Largactil, ...
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Disease relevance of Largactil


Psychiatry related information on Largactil


High impact information on Largactil


Chemical compound and disease context of Largactil


Biological context of Largactil

  • Using distinct vesicular transport mutants and chlorpromazine, we have identified the eIF2alpha kinase Gcn2p and the eIF4E binding protein Eap1p as major mediators of the translation attenuation response [14].
  • Sir3 hyperphosphorylation is correlated with reduced subtelomeric silencing, increased subtelomeric cell wall gene expression, and stress resistance to chlorpromazine, but does not affect the silent HML and rDNA loci [20].
  • However, two phenotypically distinct memory T cell populations were established depending on the system used; whereas those for anti-KLH antibody response were enriched in the fraction expression 6C10 (Fr. III), memory T cells for the allogeneic MLR lacked such expression (Fr. IV) [21].
  • This alteration of phenotype and interleukin secretion was also demonstrable when starting with 3G11+6C10- cells (Fr. I), the fraction that secretes IL-2 exclusively upon activation [21].
  • Stomatocytosis and endocytosis were induced in normal intact human erythrocytes by incubation with three agents: primaquine, vinblastine, and chlorpromazine, each of which has its own requirements and time course for producing endocytosis [22].

Anatomical context of Largactil


Associations of Largactil with other chemical compounds


Gene context of Largactil


Analytical, diagnostic and therapeutic context of Largactil

  • In the F2 cells, few detectable R-type particles and cytoplasmic vacuoles were revealed by electron microscopy [23].
  • In the 32 hours after treatment there was an overall reduction in stool output of 66 +/- 5% in the chlorpromazine-treated patients [28].
  • Effectiveness of the chlorpromazine was determined by comparing oral therapy failure rates, purging rates, vomiting rates, i.v. fluid requirements and hospitalization time in groups of the patients receiving and not receiving the drug [33].
  • METHODS: We did a meta-analysis of all randomised controlled trials in which new generation antipsychotics had been compared with low-potency (equivalent or less potent than chlorpromazine) conventional drugs [34].
  • The findings are of practical significance for readings of abnormality in the ECG of phenothiazine-treated patients [35].


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  3. Chlorpromazine and its metabolites alter polymerization and gelation of actin. Elias, E., Boyer, J.L. Science (1979) [Pubmed]
  4. Weight gain from combined phenothiazine and tricyclic therapy. Pfister, A.K. JAMA (1978) [Pubmed]
  5. Hirsutism associated with long-term phenothiazine neuroleptic therapy. Phillips, P., Shraberg, D., Weitzel, W.D. JAMA (1979) [Pubmed]
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  7. Subjective response as a predictor of outcome in pharmacotherapy: the consumer has a point. Van Putten, T., May, P.R. Arch. Gen. Psychiatry (1978) [Pubmed]
  8. Is loxapine more effective than chlorpromazine in paranoid schizophrenia? Rifkin, A., Rieder, E., Sarantakos, S., Saraf, K., Kane, J. The American journal of psychiatry. (1984) [Pubmed]
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  10. Gilles de la Tourette syndrome after long-term chlorpromazine therapy. Klawans, H.L., Falk, D.K., Nausieda, P.A., Weiner, W.J. Neurology (1978) [Pubmed]
  11. Galactorrhea: a study of 235 cases, including 48 with pituitary tumors. Kleinberg, D.L., Noel, G.L., Frantz, A.G. N. Engl. J. Med. (1977) [Pubmed]
  12. Concurrent inhibition by chlorpromazine of concanavalin A-induced lymphocyte aggregation and mitogenesis. Ferguson, R.M., Schmidtke, J.R., Simmons, R.L. Nature (1975) [Pubmed]
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  14. A membrane transport defect leads to a rapid attenuation of translation initiation in Saccharomyces cerevisiae. Deloche, O., de la Cruz, J., Kressler, D., Doère, M., Linder, P. Mol. Cell (2004) [Pubmed]
  15. Drug and neurotransmitter receptors. New perspectives with clinical relevance. Snyder, S.H. JAMA (1989) [Pubmed]
  16. Protective effect of chlorpromazine on endotoxin toxicity and TNF production in glucocorticoid-sensitive and glucocorticoid-resistant models of endotoxic shock. Gadina, M., Bertini, R., Mengozzi, M., Zandalasini, M., Mantovani, A., Ghezzi, P. J. Exp. Med. (1991) [Pubmed]
  17. Antitumor and toxic effects of combination chemotherapy with bleomycin and a phenothiazine anticalmodulin agent. Hait, W.N., Lazo, J.S., Chen, D.L., Gallichio, V.S., Filderman, A.E. J. Natl. Cancer Inst. (1988) [Pubmed]
  18. Drug-induced anti-histone autoantibodies display two patterns of reactivity with substructures of chromatin. Burlingame, R.W., Rubin, R.L. J. Clin. Invest. (1991) [Pubmed]
  19. Hypotension due to chlorpromazine. Relation to cigarette smoking, blood pressure, and dosage. Swett, C., Cole, J.O., Hartz, S.C., Shapiro, S., Slone, D. Arch. Gen. Psychiatry (1977) [Pubmed]
  20. Regulation of subtelomeric silencing during stress response. Ai, W., Bertram, P.G., Tsang, C.K., Chan, T.F., Zheng, X.F. Mol. Cell (2002) [Pubmed]
  21. Phenotypic and functional alteration of CD4+ T cells after antigen stimulation. Resolution of two populations of memory T cells that both secrete interleukin 4. Hayakawa, K., Hardy, R.R. J. Exp. Med. (1989) [Pubmed]
  22. Alteration of membrane phospholipid bilayer organization in human erythrocytes during drug-induced endocytosis. Schrier, S.L., Chiu, D.T., Yee, M., Sizer, K., Lubin, B. J. Clin. Invest. (1983) [Pubmed]
  23. Separation of cells containing R-type virus-like particles from a simian virus 40-induced hamster tumor cell line. Bergman, D.G., Blakeslee, J.R., Wolff, D.A. J. Natl. Cancer Inst. (1977) [Pubmed]
  24. Effects of chlorpromazine hydrochloride and its metabolites on Mg2+- and Na+,K+-ATPase activities of canalicular-enriched rat liver plasma membranes. Samuels, A.M., Carey, M.C. Gastroenterology (1978) [Pubmed]
  25. Endotoxin protects against chlorpromazine-induced cholestasis in the isolated perfused rat liver. Utili, R., Abernathy, C.O., Zimmerman, H.J., Gaeta, G.B., Adinolfi, L., Lukacs, L. Gastroenterology (1981) [Pubmed]
  26. Reversal of cyclic AMP-mediated intestinal secretion in mice by chlorpromazine. Holmgren, J., Lange, S., Lönnroth, I. Gastroenterology (1978) [Pubmed]
  27. Circumvention of multiple-drug resistance in human cancer cells by thioridazine, trifluoperazine, and chlorpromazine. Akiyama, S., Shiraishi, N., Kuratomi, Y., Nakagawa, M., Kuwano, M. J. Natl. Cancer Inst. (1986) [Pubmed]
  28. Chlorpromazine reduces fluid-loss in cholera. Rabbani, G.H., Greenough, W.B., Holmgren, J., Lönnroth, I. Lancet (1979) [Pubmed]
  29. Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. Adams, C.M., Goldstein, J.L., Brown, M.S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  30. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). Matsushita, M., Kuraya, M., Hamasaki, N., Tsujimura, M., Shiraki, H., Fujita, T. J. Immunol. (2002) [Pubmed]
  31. Human T lymphocyte activation by tumor promoters: role of protein kinase C. Isakov, N., Altman, A. J. Immunol. (1987) [Pubmed]
  32. Purification and properties of the dnaJ replication protein of Escherichia coli. Zylicz, M., Yamamoto, T., McKittrick, N., Sell, S., Georgopoulos, C. J. Biol. Chem. (1985) [Pubmed]
  33. The use of chlorpromazine in the treatment of cholera and other severe acute watery diarrheal diseases. Islam, M.R., Sack, D.A., Holmgren, J., Bardhan, P.K., Rabbani, G.H. Gastroenterology (1982) [Pubmed]
  34. New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis. Leucht, S., Wahlbeck, K., Hamann, J., Kissling, W. Lancet (2003) [Pubmed]
  35. Phenothiazine-induced ECG abnormalities: effect of a glucose load. Chouinard, G., Annable, L. Arch. Gen. Psychiatry (1977) [Pubmed]
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