Catalytic C-C bond formation via capture of hydrogenation intermediates.
Although catalytic hydrogenation has been practiced for over a century, use of hydrogen as a terminal reductant in catalytic C-C bond formation has been restricted to processes involving migratory insertion of carbon monoxide, e.g., alkene hydroformylation and related Fischer-Tropsch-type reactions. In an effort to develop hydrogenation as a new method for catalytic cross-coupling, a catalytic system enabling capture of hydrogenation intermediates was recently developed in our lab. These results support the feasibility of developing a broad new family of hydrogen-mediated C-C bond formations.[1]References
- Catalytic C-C bond formation via capture of hydrogenation intermediates. Jang, H.Y., Krische, M.J. Acc. Chem. Res. (2004) [Pubmed]
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