The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

formalin     methanal

Synonyms: Aldacide, Formalaz, Lysoform, Morbicid, aldehydes, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of methanal


Psychiatry related information on methanal


High impact information on methanal


Chemical compound and disease context of methanal


Biological context of methanal


Anatomical context of methanal


Associations of methanal with other chemical compounds

  • The anti-inflammatory properties of HO-1 are thought to rely on the ability of this enzyme to degrade heme and generate bilirubin, free iron and carbon monoxide [31].
  • We report here that in rat the beta-adrenoceptor antagonist (-)propranolol reduces or abolishes the rapid increase of immunoreactive beta-endorphin levels during some stress stimuli (footshock, passive avoidance, restraint) but not during others (ether, formalin, laparotomy) [32].
  • Heme oxygenase (HO) enzyme activity results in the degradation of heme and the production of iron, carbon monoxide, and biliverdin [33].
  • Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus [34].
  • There is limited direct evidence for changes in the earth's oxidizing capacity since recent preindustrial times when, because of industrial and population growth, increasing amounts of O3 precursor trace gases (carbon monoxide, nitrogen oxides, and hydrocarbons) have been released into the atmosphere [35].
  • The factors that influence this dichotomy are discussed and a general mechanistic model is proposed for aldol reactions with alpha-heteroatom-substituted aldehydes [36].

Gene context of methanal


Analytical, diagnostic and therapeutic context of methanal

  • Transplantation of kidneys from a donor with carbon monoxide poisoning [42].
  • On each test day, subjects performed two symptom-limited incremental exercise tests on a treadmill; the tests were separated by a recovery period and 50 to 70 minutes of exposure to either room air or air containing one of two concentrations of carbon monoxide (117 +/- 4.4 ppm or 253 +/- 6.1 ppm) [27].
  • In this study, five of six macaques were protected against vaginal challenge when immunized with formalin-treated SIV in biodegradable microspheres by the intramuscular plus oral or plus intratracheal route [43].
  • Resonance Raman spectroscopy has been used to identify both C-O stretching and metal-CO stretching vibrations of the carbon monoxide adduct of the enzyme [44].
  • Such values can be extimated by dose-response analysis of several epidemiological studies and by extrapolation of blood concentrations at different rates of intake for certain smoke components, such as carbon monoxide [45].


  1. Cytochrome P-4502E1: its physiological and pathological role. Lieber, C.S. Physiol. Rev. (1997) [Pubmed]
  2. Carbon monoxide toxicity in a man working outdoors with a gasoline-powered hydraulic machine. Huff, J.S., Kardon, E. N. Engl. J. Med. (1989) [Pubmed]
  3. Detection of intrapulmonary hemorrhage with carbon monoxide uptake. Application in goodpasture's syndrome. Ewan, P.W., Jones, H.A., Rhodes, C.G., Hughes, J.M. N. Engl. J. Med. (1976) [Pubmed]
  4. Nicotine and carbon monoxide content of cigarette smoke and the risk of myocardial infarction in young men. Kaufman, D.W., Helmrich, S.P., Rosenberg, L., Miettinen, O.S., Shapiro, S. N. Engl. J. Med. (1983) [Pubmed]
  5. Diffusing capacity for carbon monoxide as a predictor of gas exchange during exercise. Sue, D.Y., Oren, A., Hansen, J.E., Wasserman, K. N. Engl. J. Med. (1987) [Pubmed]
  6. Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. Andrè, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., Baraldi, P.G., Poole, D.P., Bunnett, N.W., Geppetti, P., Patacchini, R. J. Clin. Invest. (2008) [Pubmed]
  7. Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway. Rosado, I.V., Langevin, F., Crossan, G.P., Takata, M., Patel, K.J. Nat. Struct. Mol. Biol. (2011) [Pubmed]
  8. A comparison of sustained-release bupropion and placebo for smoking cessation. Hurt, R.D., Sachs, D.P., Glover, E.D., Offord, K.P., Johnston, J.A., Dale, L.C., Khayrallah, M.A., Schroeder, D.R., Glover, P.N., Sullivan, C.R., Croghan, I.T., Sullivan, P.M. N. Engl. J. Med. (1997) [Pubmed]
  9. Transmission of Creutzfeldt-Jakob disease from formalin-fixed, paraffin-embedded human brain tissue. Brown, P., Gibbs, C.J., Gajdusek, D.C., Cathala, F., LaBauge, R. N. Engl. J. Med. (1986) [Pubmed]
  10. Pulmonary hazards of smoking marijuana as compared with tobacco. Wu, T.C., Tashkin, D.P., Djahed, B., Rose, J.E. N. Engl. J. Med. (1988) [Pubmed]
  11. Prenatal exposure to carbon monoxide: learning and memory deficits. Mactutus, C.F., Fechter, L.D. Science (1984) [Pubmed]
  12. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Zimmer, A., Zimmer, A.M., Hohmann, A.G., Herkenham, M., Bonner, T.I. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  13. Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s. Pylypenko, O., Schlichting, I. Annu. Rev. Biochem. (2004) [Pubmed]
  14. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Ryter, S.W., Alam, J., Choi, A.M. Physiol. Rev. (2006) [Pubmed]
  15. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Roman, R.J. Physiol. Rev. (2002) [Pubmed]
  16. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Bergman, E.N. Physiol. Rev. (1990) [Pubmed]
  17. A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group. Greco, D., Salmaso, S., Mastrantonio, P., Giuliano, M., Tozzi, A.E., Anemona, A., Ciofi degli Atti, M.L., Giammanco, A., Panei, P., Blackwelder, W.C., Klein, D.L., Wassilak, S.G. N. Engl. J. Med. (1996) [Pubmed]
  18. Routine pulmonary function tests during bleomycin therapy. Tests may be ineffective and potentially misleading. Lewis, B.M., Izbicki, R. JAMA (1980) [Pubmed]
  19. Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus. Crow, M.K. J. Clin. Invest. (1985) [Pubmed]
  20. The role of lysosomal elastase in the digestion of Escherichia coli proteins by human polymorphonuclear leukocytes: experiments with living leukocytes. Blondin, J., Janoff, A. J. Clin. Invest. (1976) [Pubmed]
  21. Exacerbation of eczema by formalin-containing hepatitis B vaccine in formaldehyde-allergic patient. Ring, J. Lancet (1986) [Pubmed]
  22. Allelic loss of chromosome 18q and prognosis in colorectal cancer. Jen, J., Kim, H., Piantadosi, S., Liu, Z.F., Levitt, R.C., Sistonen, P., Kinzler, K.W., Vogelstein, B., Hamilton, S.R. N. Engl. J. Med. (1994) [Pubmed]
  23. Glucose-induced exertional fatigue in muscle phosphofructokinase deficiency. Haller, R.G., Lewis, S.F. N. Engl. J. Med. (1991) [Pubmed]
  24. How carbon monoxide reduces plasma volume. Stonesifer, L.D. N. Engl. J. Med. (1978) [Pubmed]
  25. Polar appearance and nonligand induced spreading of measles virus hemagglutinin at the surface of chronically infected cells. Ehrnst, A., Sundqvist, K.G. Cell (1975) [Pubmed]
  26. Reversal of long-term potentiation by inhibitors of haem oxygenase. Stevens, C.F., Wang, Y. Nature (1993) [Pubmed]
  27. Short-term effects of carbon monoxide exposure on the exercise performance of subjects with coronary artery disease. Allred, E.N., Bleecker, E.R., Chaitman, B.R., Dahms, T.E., Gottlieb, S.O., Hackney, J.D., Pagano, M., Selvester, R.H., Walden, S.M., Warren, J. N. Engl. J. Med. (1989) [Pubmed]
  28. The identification of calmodulin-binding sites on mitochondria in cultured 3T3 cells. Pardue, R.L., Kaetzel, M.A., Hahn, S.H., Brinkley, B.R., Dedman, J.R. Cell (1981) [Pubmed]
  29. Formalin infiltration of the ductus arteriosus. A method for palliation of infants with selected congenital cardiac lesions. Rudolph, A.M., Heymann, M.A., Fishman, N., Lakier, J.B. N. Engl. J. Med. (1975) [Pubmed]
  30. Absence of cytochrome b-245 in chronic granulomatous disease. A multicenter European evaluation of its incidence and relevance. Segal, A.W., Cross, A.R., Garcia, R.C., Borregaard, N., Valerius, N.H., Soothill, J.F., Jones, O.T. N. Engl. J. Med. (1983) [Pubmed]
  31. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Soares, M.P., Lin, Y., Anrather, J., Csizmadia, E., Takigami, K., Sato, K., Grey, S.T., Colvin, R.B., Choi, A.M., Poss, K.D., Bach, F.H. Nat. Med. (1998) [Pubmed]
  32. Beta-adrenoceptor activation mediates stress-induced secretion of beta-endorphin-related peptides from intermediate but not anterior pituitary. Berkenbosch, F., Tilders, F.J., Vermes, I. Nature (1983) [Pubmed]
  33. Different faces of the heme-heme oxygenase system in inflammation. Wagener, F.A., Volk, H.D., Willis, D., Abraham, N.G., Soares, M.P., Adema, G.J., Figdor, C.G. Pharmacol. Rev. (2003) [Pubmed]
  34. Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Zhuo, M., Small, S.A., Kandel, E.R., Hawkins, R.D. Science (1993) [Pubmed]
  35. The oxidizing capacity of the earth's atmosphere: probable past and future changes. Thompson, A.M. Science (1992) [Pubmed]
  36. Aldol reactions between L-erythrulose derivatives and chiral alpha-amino and alpha-fluoro aldehydes: competition between Felkin-Anh and Cornforth transition states. Díaz-Oltra, S., Carda, M., Murga, J., Falomir, E., Marco, J.A. Chemistry (2008) [Pubmed]
  37. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Lee, T.S., Chau, L.Y. Nat. Med. (2002) [Pubmed]
  38. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. Brouard, S., Otterbein, L.E., Anrather, J., Tobiasch, E., Bach, F.H., Choi, A.M., Soares, M.P. J. Exp. Med. (2000) [Pubmed]
  39. Detection and functional studies of p60-65 (Tac antigen) on activated human B cells. Jung, L.K., Hara, T., Fu, S.M. J. Exp. Med. (1984) [Pubmed]
  40. Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis. Cominelli, F., Nast, C.C., Duchini, A., Lee, M. Gastroenterology (1992) [Pubmed]
  41. Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes. Mishra, S., Fujita, T., Lama, V.N., Nam, D., Liao, H., Okada, M., Minamoto, K., Yoshikawa, Y., Harada, H., Pinsky, D.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  42. Transplantation of kidneys from a donor with carbon monoxide poisoning. Hébert, M.J., Boucher, A., Beaucage, G., Girard, R., Dandavino, R. N. Engl. J. Med. (1992) [Pubmed]
  43. Protection against vaginal SIV transmission with microencapsulated vaccine. Marx, P.A., Compans, R.W., Gettie, A., Staas, J.K., Gilley, R.M., Mulligan, M.J., Yamshchikov, G.V., Chen, D., Eldridge, J.H. Science (1993) [Pubmed]
  44. Nature's carbonylation catalyst: Raman spectroscopic evidence that carbon monoxide binds to iron, not nickel, in CO dehydrogenase. Qiu, D., Kumar, M., Ragsdale, S.W., Spiro, T.G. Science (1994) [Pubmed]
  45. Low-risk cigarettes: a prescription. Gori, G.B. Science (1976) [Pubmed]
WikiGenes - Universities