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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cytotoxic saponins from Schefflera rotundifolia.

Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia ( Ten) Frodin (Araliaceae) together with two known benzyl glycosides. Their structures were established using 1D- and 2D-NMR spectroscopy and mass spectrometry. The antiproliferative activity of all compounds was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, and WEHI-164. Compounds 7 and 8, having betulinic acid as aglycone, were the most active constituents.[1]


  1. Cytotoxic saponins from Schefflera rotundifolia. Braca, A., Autore, G., De Simone, F., Marzocco, S., Morelli, I., Venturella, F., De Tommasi, N. Planta Med. (2004) [Pubmed]
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