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Disease relevance of Araliaceae


High impact information on Araliaceae

  • Little is known about the metabolic origin of petroselinic acid (18:1 delta 6cis), the principal fatty acid of the seed oil of most Umbelliferae, Araliaceae, and Garryaceae species [3].
  • Three linear molecules of a polyacetylene structure were isolated from the East African medicinal plant Cussonia zimmermannii Harms and shown to allosterically stimulate GABAA receptors [4].
  • Synthesis of beta-Boswellic acid analogues with a carboxyl group at C-17 isolated from the bark of Schefflera octophylla [5].
  • In the present study, we assayed a number of compounds that were isolated from Panax ginseng C.A. Meyer (Araliaceae) for an ability to protect rat cortical cell cultures from the deleterious effects of the neurotoxicant, glutamate [6].
  • Eight new oleanane and lupane saponins (1-8) as well as two new benzyl glycosides (9 and 10) were isolated from the aerial parts of Schefflera rotundifolia (Ten) Frodin (Araliaceae) together with two known benzyl glycosides [7].

Chemical compound and disease context of Araliaceae


Biological context of Araliaceae

  • A. Meyer (Araliaceae) inhibited the 2-DG uptake (IC50 = 76.3 microM) in a competitive fashion with respect to 2-DG (Ki = 0.32 mM) and the growth of MT-4 cells with CC50 of 84.4 microM, whereas it did not show any significant anti-HIV-1 activity [9].
  • Triterpenoids, ursolic acid (1) and 23-hydroxyursolic acid (2) were obtained from the hydrolysis of BuOH fraction of Cussonia bancoensis extract to test antinociceptive and anti-inflammatory effect of C. bancoensis (Araliaceae) [10].

Anatomical context of Araliaceae


Associations of Araliaceae with chemical compounds


Gene context of Araliaceae

  • Orally administered Araliaceae saponin extracts did not affect plasma lactic acid, glucagon, insulin or liver glycogen levels in exercised rats and did not prolong their swimming time [19].
  • Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor [20].
  • One new triterpenoidal saponin, saponin F(2) has been isolated from the bark of Kalopanax pictum Nakai var. typicum (Araliaceae), together with one known saponin, kizuta saponin K12 (1) [21].


  1. Hepatoprotective effect of majonoside R2, the major saponin from Vietnamese ginseng (Panax vietnamensis). Tran, Q.L., Adnyana, I.K., Tezuka, Y., Harimaya, Y., Saiki, I., Kurashige, Y., Tran, Q.K., Kadota, S. Planta Med. (2002) [Pubmed]
  2. Allergic contact dermatitis from falcarinol isolated from Schefflera arboricola. Hansen, L., Hammershøy, O., Boll, P.M. Contact Derm. (1986) [Pubmed]
  3. Expression of a coriander desaturase results in petroselinic acid production in transgenic tobacco. Cahoon, E.B., Shanklin, J., Ohlrogge, J.B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Novel plant substances acting as beta subunit isoform-selective positive allosteric modulators of GABAA receptors. Baur, R., Simmen, U., Senn, M., Séquin, U., Sigel, E. Mol. Pharmacol. (2005) [Pubmed]
  5. Synthesis of beta-Boswellic acid analogues with a carboxyl group at C-17 isolated from the bark of Schefflera octophylla. Bore, L., Honda, T., Gribble, G.W. J. Org. Chem. (2000) [Pubmed]
  6. Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. Kim, Y.C., Kim, S.R., Markelonis, G.J., Oh, T.H. J. Neurosci. Res. (1998) [Pubmed]
  7. Cytotoxic saponins from Schefflera rotundifolia. Braca, A., Autore, G., De Simone, F., Marzocco, S., Morelli, I., Venturella, F., De Tommasi, N. Planta Med. (2004) [Pubmed]
  8. The major allergen of Dendropanax trifidus Makino. Oka, K., Saito, F., Yasuhara, T., Sugimoto, A. Contact Derm. (1997) [Pubmed]
  9. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Hasegawa, H., Matsumiya, S., Uchiyama, M., Kurokawa, T., Inouye, Y., Kasai, R., Ishibashi, S., Yamasaki, K. Planta Med. (1994) [Pubmed]
  10. In vivo anti-nociceptive and anti-inflammatory effect of the two triterpenes, ursolic acid and 23-hydroxyursolic acid, from Cussonia bancoensis. Tapondjou, L.A., Lontsi, D., Sondengam, B.L., Choi, J., Lee, K.T., Jung, H.J., Park, H.J. Arch. Pharm. Res. (2003) [Pubmed]
  11. Tyrosine kinase inhibitors from the rainforest tree Polyscias murrayi. Buchanan, M.S., Carroll, A.R., Edser, A., Parisot, J., Addepalli, R., Quinn, R.J. Phytochemistry (2005) [Pubmed]
  12. Acanthoic acid inhibits IL-8 production via MAPKs and NF-kappaB in a TNF-alpha-stimulated human intestinal epithelial cell line. Kim, J.A., Kim, D.K., Jin Tae, n.u.l.l., Kang, O.H., Choi, Y.A., Choi, S.C., Kim, T.H., Nah, Y.H., Choi, S.J., Kim, Y.H., Bae, K.H., Lee, Y.M. Clin. Chim. Acta (2004) [Pubmed]
  13. Effect of Panax ginseng extract (G115) on angiotensin-converting enzyme (ACE) activity and nitric oxide (NO) production. Persson, I.A., Dong, L., Persson, K. Journal of ethnopharmacology. (2006) [Pubmed]
  14. Isolation from Cussonia barteri of 1'-O-chlorogenoylchlorogenic acid and 1'-O-chlorogenoylneochlorogenic acid, a new type of quinic acid esters. Papajewski, S., Vogler, B., Conrad, J., Klaiber, I., Roos, G., Walter, C.U., Süssmuth, R., Kraus, W. Planta Med. (2001) [Pubmed]
  15. Triterpenoid saponins from Schefflera arboricola. Melek, F.R., Miyase, T., Khalik, S.M., El-Gindi, M.R. Phytochemistry (2003) [Pubmed]
  16. Oleanane saponins from Polyscias fruticosa. Vo, D.H., Yamamura, S., Ohtani, K., Kasai, R., Yamasaki, K., Nguyen, T.N., Hoang, M.C. Phytochemistry (1998) [Pubmed]
  17. Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production. Tapondjou, L.A., Lontsi, D., Sondengam, B.L., Shaheen, F., Choudhary, M.I., Atta-ur-Rahman, n.u.l.l., van Heerden, F.R., Park, H.J., Lee, K.T. J. Nat. Prod. (2003) [Pubmed]
  18. A new dammarane-type triterpene glycoside from Polyscias fulva. Bedir, E., Toyang, N.J., Khan, I.A., Walker, L.A., Clark, A.M. J. Nat. Prod. (2001) [Pubmed]
  19. The physiological effects of Aralia, Panax and Eleutherococcus on exercised rats. Martinez, B., Staba, E.J. Jpn. J. Pharmacol. (1984) [Pubmed]
  20. Inhibitory lignans against NFAT transcription factor from Acanthopanax koreanum. Cai, X.F., Lee, I.S., Dat, N.T., Shen, G., Kang, J.S., Kim, D.H., Kim, Y.H. Arch. Pharm. Res. (2004) [Pubmed]
  21. Triterpenoidal saponins from the bark of Kalopanax pictum var. typicum. Cho, S.H., Hahn, D.R. Arch. Pharm. Res. (1991) [Pubmed]
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