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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Absence of cholinergic deficits in "pure" vascular dementia.

Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases (9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.[1]


  1. Absence of cholinergic deficits in "pure" vascular dementia. Perry, E., Ziabreva, I., Perry, R., Aarsland, D., Ballard, C. Neurology (2005) [Pubmed]
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