Disease relevance of Dementia, Vascular

• Cerebral amyloid angiopathy: a microvascular link between parenchymal and vascular dementia [1]?
• Nicotinic acetylcholine receptor distribution in Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and vascular dementia: in vitro binding study using 5-[(125)i]-a-85380 [2].
• RESULTS: Levels of GS were significantly increased in lumbar CSF from patients with AD (20+/-12 pg/mL; P = .01) and to a lesser extent in patients with vascular dementia and amyotrophic lateral sclerosis [3].
• However, high CSF-tau is preferentially found in patients with vascular dementia without progressive leukoaraiosis, which may constitute a group with concomitant Alzheimer's disease pathology [4].
• Forty subjects participated in this study: 28 patients with brain multiple sclerosis (MS), 6 patients with subcortical ischemic vascular dementia (SIVD), and 6 patients with lacunar white matter infarcts (LI) [5].

Psychiatry related information on Dementia, Vascular

• CADASIL (for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) causes a type of stroke and dementia whose key features include recurrent subcortical ischaemic events and vascular dementia and which is associated with diffuse white-matter abnormalities on neuroimaging [6].
• Age-adjusted HR's of Alzheimer's disease and vascular dementia associated with higher levels of total estradiol (per SD increase) were 1.24 (95% CI 0.87-1.76) and 2.19 (95% CI 1.22-3.92), respectively [7].
• Non-suppression of plasma cortisol was found in 28 out of 48 patients (58%) with senile dementia and all patients with arteriosclerotic dementia or acute confusional states [8].
• OBJECTIVE: Authors compared delusions, hallucinations, and misidentification delusions in Alzheimer disease (AD) and vascular dementia (VaD) patients [9].
• Efficacy and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the Scandinavian Multi-Infarct Dementia Trial [10].

High impact information on Dementia, Vascular

• We found generally similar relationships of alcohol use with Alzheimer disease and vascular dementia [11].
• Prevalence estimates for the cohort were 9.3% for dementia (all cause), 5.4% for Alzheimer disease (primary or contributing), and 4.2% for vascular dementia (primary or contributing) [12].
• Association of apolipoprotein E E4 with vascular dementia [13].
• The objective of this article is to compare number and size of neurons in CA1 in AD versus ischemic vascular dementia [14].
• Furthermore, elevated aluminium content in multiple cortical regions was not found in 2 vascular dementias of the elderly [15].

Chemical compound and disease context of Dementia, Vascular

• Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias [16].
• Accordingly, serum homocysteine is increased in patients with vascular dementia but is also increased in clinically diagnosed and histologically confirmed AD [17].
• OBJECTIVE: To assess the relationship between impaired glucose tolerance and both vascular dementia and AD [18].
• Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia [19].
• The 2 patients with vascular dementia showed clinical improvement with marked increases in the NAA/Cre ratio and mini-mental score [20].
• Cholinesterase inhibitors and memantine produce small benefits in cognition of uncertain clinical significance in patients with mild to moderate vascular dementia [21].

Biological context of Dementia, Vascular

• In participants with the apolipoprotein-E epsilon 4 genotype and an atherosclerosis score of 2 or 3 the odds ratio for all dementia was 4.5 (2.0-10.1; p < 0.001), for Alzheimer's disease was 3.9 (1.6-9.6; p = 0.002), and for vascular dementia was 19.8 (4.1-95.0; p < 0.001) [22].
• Apolipoprotein E epsilon 4 allele frequency in vascular dementia and Alzheimer's disease [23].
• Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia [24].
• Hemostasis abnormalities were more frequent and marked in vascular dementia, being expressed as significant increases of plasminogen activator inhibitor type 1, von Willebrand factor, D-dimer and activated factor VII [25].
• Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia [26].

Anatomical context of Dementia, Vascular

• Cerebrospinal fluid pyruvate levels in Alzheimer's disease and vascular dementia [27].
• Caudate nucleus dopamine d(2) receptors in vascular dementia [28].
• Modulation of neuronal and glial cell function by adenosine and neuroprotection in vascular dementia [29].
• Immunohistochemical localizing of the proliferation of Ki67 nuclei and doublecortin positive cells were performed in the prefrontal cortex of normal aged and vascular dementia (multiple infarct dementia) patients [30].
• METHODS: Serum levels of IGF-1 and HGF, carotid artery intima-media thickness (IMT), and Mini-Mental State Examination (MMSE) scores were determined in 60 subjects over 65 years old (35 patients with vascular dementia and 25 without dementia) [31].

Gene context of Dementia, Vascular

• Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia [32].
• Serum anti-GFAP and anti-S100 autoantibodies in brain aging, Alzheimer's disease and vascular dementia [33].
• Mutations in the NOTCH3 gene (NOTCH3) are responsible for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an adult-onset hereditary angiopathy leading to ischemic episodes, vascular dementia and other neurologic deficits [34].
• MTHFR is a key enzyme in the metabolism of homocysteine and elevated levels of that amino acid have been associated to Vascular Dementia and AD [35].
• APOE-epsilon 4 in patients with Alzheimer disease and vascular dementia [36].

Analytical, diagnostic and therapeutic context of Dementia, Vascular

• The role of heredity in late-onset Alzheimer disease and vascular dementia. A twin study [37].
• Recent epidemiologic studies reappraised the possibility that vascular risk factors might play a role in the pathogenesis not only of vascular dementia (VaD) but also of Alzheimer disease (AD) [19].
• Donepezil in vascular dementia: combined analysis of two large-scale clinical trials [38].
• To assess nonlinear EEG activity in patients with Alzheimer's disease (AD) and vascular dementia (VaD), the authors estimated the correlation dimension (D2) and the first positive Lyapunov exponent (L1) of the EEGs in both patients and age-matched healthy control subjects [39].
• Caudate nucleus dopamine (DA) D(2) receptors were studied in patients with vascular dementia (VaD) and in a control group using [(3)H]raclopride as a radioligand [28].

References