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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity.

Two new furo-1,2-naphthoquinones, crataequinones A (1) and B (2), were isolated from the fruits of Crataegus pinnatifida. The structures of two new compounds were determined as 11,12-dimethoxy-3,4-furo-1,2-naphthoquinone (1) and 11,12-dimethoxy-5-hydroxy-3,4-furo-1,2-naphthoquinone (2) by spectroscopic analysis. The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 microM, respectively, against the expression of intercellular adhesion molecule-1 ( ICAM-1).[1]

References

  1. Furo-1,2-naphthoquinones from Crataegus pinnatifida with ICAM-1 expression inhibition activity. Min, B.S., Huong, H.T., Kim, J.H., Jun, H.J., Na, M.K., Nam, N.H., Lee, H.K., Bae, K., Kang, S.S. Planta Med. (2004) [Pubmed]
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