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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women.

The RAD52 gene is involved in the homologous recombination repair pathway and is a plausible candidate ovarian cancer predisposition gene. We undertook a case-control comparison of 508 epithelial ovarian cancer cases (91 low malignant potential and 417 invasive) and 298 healthy controls to assess the RAD52 Y415X polymorphism as a risk factor for epithelial ovarian cancer in Australian women. Heterozygote frequencies of 2.6 and 4% were observed among cases and controls, respectively. The risk estimate was 0.55 (95%CI 0.24-1.24), suggesting that the RAD52 Y415X polymorphism is not associated with epithelial ovarian cancer in Australian women.[1]

References

  1. RAD52 Y415X truncation polymorphism and epithelial ovarian cancer risk in Australian women. Kelemen, L., Spurdle, A.B., Purdie, D.M., Gertig, D., Chenevix-Trench, G. Cancer Lett. (2005) [Pubmed]
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