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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis.

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor ( ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.[1]

References

  1. Protein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis. Al-Shanqeeti, A., van Hylckama Vlieg, A., Berntorp, E., Rosendaal, F.R., Broze, G.J. Thromb. Haemost. (2005) [Pubmed]
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