The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Case-Control Studies

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Case-Control Studies


Psychiatry related information on Case-Control Studies


High impact information on Case-Control Studies

  • METHODS: We conducted a population-based case-control study of ovarian cancer among Jewish women in Israel. Women were tested for the two founder mutations in BRCA1 and the one founder mutation in BRCA2 that are known to be common among Jews [11].
  • In three of four independent case-control studies, we demonstrated an association of the mutation with MS [12].
  • The OCT-1-binding genotype, found in approximately 5% of Africans, is associated with fourfold increased susceptibility to cerebral malaria in large case-control studies of West African and East African populations, after correction for other known TNF polymorphisms and linked HLA alleles [13].
  • METHODS: Case-control studies were performed at three of the four hospitals to assess the relation of the use of clindamycin to C. difficile-associated diarrhea [14].
  • We conducted a case-control study, using medical-history reviews, serologic testing, and testing with the polymerase chain reaction for E. chaffeensis infection [15].

Chemical compound and disease context of Case-Control Studies


Biological context of Case-Control Studies


Anatomical context of Case-Control Studies


Associations of Case-Control Studies with chemical compounds

  • A case-control study based on toxicologic analyses of postmortem blood samples indicates that concentrations of both heroin and ethanol are substantial risk factors for heroin-related deaths [31].
  • We performed a case-control study looking at thiazide use and subsequent hip fracture in postmenopausal female members of the Framingham Study cohort [32].
  • DESIGN AND SETTING: Prospective, nested case-control study in the Cholesterol and Recurrent Events (CARE) trial, a randomized placebo-controlled trial of pravastatin conducted in 1989-1996 [33].
  • The relationship between truck driving and bladder cancer mortality was investigated in a case-control study in New Hampshire and Vermont. In-person interviews were conducted with the next-of-kin of 325 bladder cancer cases and 673 controls who died during 1975-79 [34].
  • In the nested case-control study, HBV carriers in the highest tertile of testosterone levels had a statistically significantly increased risk of HCC (OR = 2.06; 95% CI = 1.14--3.70) compared with those in the lowest tertile [35].

Gene context of Case-Control Studies


Analytical, diagnostic and therapeutic context of Case-Control Studies


  1. Uranium mining and lung cancer in Navajo men. Samet, J.M., Kutvirt, D.M., Waxweiler, R.J., Key, C.R. N. Engl. J. Med. (1984) [Pubmed]
  2. Endometrial cancer and estrogen use. Report of a large case-control study. Antunes, C.M., Strolley, P.D., Rosenshein, N.B., Davies, J.L., Tonascia, J.A., Brown, C., Burnett, L., Rutledge, A., Pokempner, M., Garcia, R. N. Engl. J. Med. (1979) [Pubmed]
  3. Diuretic therapy for hypertension and the risk of primary cardiac arrest. Siscovick, D.S., Raghunathan, T.E., Psaty, B.M., Koepsell, T.D., Wicklund, K.G., Lin, X., Cobb, L., Rautaharju, P.M., Copass, M.K., Wagner, E.H. N. Engl. J. Med. (1994) [Pubmed]
  4. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. Cardo, D.M., Culver, D.H., Ciesielski, C.A., Srivastava, P.U., Marcus, R., Abiteboul, D., Heptonstall, J., Ippolito, G., Lot, F., McKibben, P.S., Bell, D.M. N. Engl. J. Med. (1997) [Pubmed]
  5. Quinolone-resistant Campylobacter jejuni infections in Minnesota, 1992-1998. Investigation Team. Smith, K.E., Besser, J.M., Hedberg, C.W., Leano, F.T., Bender, J.B., Wicklund, J.H., Johnson, B.P., Moore, K.A., Osterholm, M.T. N. Engl. J. Med. (1999) [Pubmed]
  6. Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Hodgkinson, C.A., Goldman, D., Jaeger, J., Persaud, S., Kane, J.M., Lipsky, R.H., Malhotra, A.K. Am. J. Hum. Genet. (2004) [Pubmed]
  7. Re: A case-control study of hepatocellular carcinoma and the hepatitis B virus, cigarette smoking, and alcohol consumption. Yu, M.C., Henderson, B.E. Cancer Res. (1987) [Pubmed]
  8. Elevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure. Sobel, E., Dunn, M., Davanipour, Z., Qian, Z., Chui, H.C. Neurology (1996) [Pubmed]
  9. DHEA-S plasma levels and incidence of Alzheimer's disease. Hillen, T., Lun, A., Reischies, F.M., Borchelt, M., Steinhagen-Thiessen, E., Schaub, R.T. Biol. Psychiatry (2000) [Pubmed]
  10. Case-control study of IDDM. Siemiatycki, J., Colle, E., Campbell, S., Dewar, R.A., Belmonte, M.M. Diabetes Care (1989) [Pubmed]
  11. Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation. Modan, B., Hartge, P., Hirsh-Yechezkel, G., Chetrit, A., Lubin, F., Beller, U., Ben-Baruch, G., Fishman, A., Menczer, J., Ebbers, S.M., Tucker, M.A., Wacholder, S., Struewing, J.P., Friedman, E., Piura, B. N. Engl. J. Med. (2001) [Pubmed]
  12. A point mutation in PTPRC is associated with the development of multiple sclerosis. Jacobsen, M., Schweer, D., Ziegler, A., Gaber, R., Schock, S., Schwinzer, R., Wonigeit, K., Lindert, R.B., Kantarci, O., Schaefer-Klein, J., Schipper, H.I., Oertel, W.H., Heidenreich, F., Weinshenker, B.G., Sommer, N., Hemmer, B. Nat. Genet. (2000) [Pubmed]
  13. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Knight, J.C., Udalova, I., Hill, A.V., Greenwood, B.M., Peshu, N., Marsh, K., Kwiatkowski, D. Nat. Genet. (1999) [Pubmed]
  14. Epidemics of diarrhea caused by a clindamycin-resistant strain of Clostridium difficile in four hospitals. Johnson, S., Samore, M.H., Farrow, K.A., Killgore, G.E., Tenover, F.C., Lyras, D., Rood, J.I., DeGirolami, P., Baltch, A.L., Rafferty, M.E., Pear, S.M., Gerding, D.N. N. Engl. J. Med. (1999) [Pubmed]
  15. Ehrlichiosis in a golf-oriented retirement community. Standaert, S.M., Dawson, J.E., Schaffner, W., Childs, J.E., Biggie, K.L., Singleton, J., Gerhardt, R.R., Knight, M.L., Hutcheson, R.H. N. Engl. J. Med. (1995) [Pubmed]
  16. Prenatal screening for Down's syndrome with use of maternal serum markers. Haddow, J.E., Palomaki, G.E., Knight, G.J., Williams, J., Pulkkinen, A., Canick, J.A., Saller, D.N., Bowers, G.B. N. Engl. J. Med. (1992) [Pubmed]
  17. Asymptomatic gonorrhea in men: caused by gonococci with unique nutritional requirements. Crawford, C., Knapp, J.S., Hale, J., Holmes, K.K. Science (1977) [Pubmed]
  18. Declining serum cholesterol levels prior to diagnosis of colon cancer. A time-trend, case-control study. Winawer, S.J., Flehinger, B.J., Buchalter, J., Herbert, E., Shike, M. JAMA (1990) [Pubmed]
  19. A reevaluation of risk of in utero exposure to lithium. Cohen, L.S., Friedman, J.M., Jefferson, J.W., Johnson, E.M., Weiner, M.L. JAMA (1994) [Pubmed]
  20. A case-control study of caffeine and methylxanthines in benign breast disease. Lubin, F., Ron, E., Wax, Y., Black, M., Funaro, M., Shitrit, A. JAMA (1985) [Pubmed]
  21. Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Ruwende, C., Khoo, S.C., Snow, R.W., Yates, S.N., Kwiatkowski, D., Gupta, S., Warn, P., Allsopp, C.E., Gilbert, S.C., Peschu, N. Nature (1995) [Pubmed]
  22. Population-based case-control study of HER2 genetic polymorphism and breast cancer risk. Chan, K.Y., Cheung, A.N., Yip, S.P., Ko, H.H., Lai, T.W., Khoo, U.S. J. Natl. Cancer Inst. (2002) [Pubmed]
  23. DNA repair, dysplastic nevi, and sunlight sensitivity in the development of cutaneous malignant melanoma. Landi, M.T., Baccarelli, A., Tarone, R.E., Pesatori, A., Tucker, M.A., Hedayati, M., Grossman, L. J. Natl. Cancer Inst. (2002) [Pubmed]
  24. Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease. Yamada, R., Tanaka, T., Unoki, M., Nagai, T., Sawada, T., Ohnishi, Y., Tsunoda, T., Yukioka, M., Maeda, A., Suzuki, K., Tateishi, H., Ochi, T., Nakamura, Y., Yamamoto, K. Am. J. Hum. Genet. (2001) [Pubmed]
  25. Polymorphisms in DNA double-strand break repair genes and skin cancer risk. Han, J., Colditz, G.A., Samson, L.D., Hunter, D.J. Cancer Res. (2004) [Pubmed]
  26. Population-based study of tamoxifen therapy and subsequent ovarian, endometrial, and breast cancers. Cook, L.S., Weiss, N.S., Schwartz, S.M., White, E., McKnight, B., Moore, D.E., Daling, J.R. J. Natl. Cancer Inst. (1995) [Pubmed]
  27. A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma risk. Duell, E.J., Holly, E.A., Bracci, P.M., Liu, M., Wiencke, J.K., Kelsey, K.T. J. Natl. Cancer Inst. (2002) [Pubmed]
  28. trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death. Roberts, T.L., Wood, D.A., Riemersma, R.A., Gallagher, P.J., Lampe, F.C. Lancet (1995) [Pubmed]
  29. Polymorphisms within glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study. Stanulla, M., Schrappe, M., Brechlin, A.M., Zimmermann, M., Welte, K. Blood (2000) [Pubmed]
  30. A case-control study of nonrandom distribution of bleomycin-induced chromatid breaks in lymphocytes of lung cancer cases. Wu, X., Hsu, T.C., Annegers, J.F., Amos, C.I., Fueger, J.J., Spitz, M.R. Cancer Res. (1995) [Pubmed]
  31. Heroin-related deaths: new epidemiologic insights. Ruttenber, A.J., Luke, J.L. Science (1984) [Pubmed]
  32. Thiazide diuretics and the risk of hip fracture. Results from the Framingham Study. Felson, D.T., Sloutskis, D., Anderson, J.J., Anthony, J.M., Kiel, D.P. JAMA (1991) [Pubmed]
  33. Low-density lipoprotein size, pravastatin treatment, and coronary events. Campos, H., Moye, L.A., Glasser, S.P., Stampfer, M.J., Sacks, F.M. JAMA (2001) [Pubmed]
  34. Truck driving and bladder cancer mortality in rural New England. Hoar, S.K., Hoover, R. J. Natl. Cancer Inst. (1985) [Pubmed]
  35. Androgen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma. Yu, M.W., Cheng, S.W., Lin, M.W., Yang, S.Y., Liaw, Y.F., Chang, H.C., Hsiao, T.J., Lin, S.M., Lee, S.D., Chen, P.J., Liu, C.J., Chen, C.J. J. Natl. Cancer Inst. (2000) [Pubmed]
  36. Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer. Helzlsouer, K.J., Selmin, O., Huang, H.Y., Strickland, P.T., Hoffman, S., Alberg, A.J., Watson, M., Comstock, G.W., Bell, D. J. Natl. Cancer Inst. (1998) [Pubmed]
  37. Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1. McGlynn, K.A., Rosvold, E.A., Lustbader, E.D., Hu, Y., Clapper, M.L., Zhou, T., Wild, C.P., Xia, X.L., Baffoe-Bonnie, A., Ofori-Adjei, D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  38. The multidrug resistance-associated protein 3 (MRP3) is associated with a poor outcome in childhood ALL and may account for the worse prognosis in male patients and T-cell immunophenotype. Steinbach, D., Wittig, S., Cario, G., Viehmann, S., Mueller, A., Gruhn, B., Haefer, R., Zintl, F., Sauerbrey, A. Blood (2003) [Pubmed]
  39. Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK. Wang, H., Tan, W., Hao, B., Miao, X., Zhou, G., He, F., Lin, D. Cancer Res. (2003) [Pubmed]
  40. Thrombomodulin deficiency in human diabetic nerve microvasculature. Hafer-Macko, C.E., Ivey, F.M., Gyure, K.A., Sorkin, J.D., Macko, R.F. Diabetes (2002) [Pubmed]
  41. Dietary history methods for epidemiologic studies: application in a case-control study of vitamin A and lung cancer. Hankin, J.H., Kolonel, L.N., Hinds, M.W. J. Natl. Cancer Inst. (1984) [Pubmed]
  42. Insulin-like growth factor 1 and prostate cancer risk: a population-based, case-control study. Wolk, A., Mantzoros, C.S., Andersson, S.O., Bergström, R., Signorello, L.B., Lagiou, P., Adami, H.O., Trichopoulos, D. J. Natl. Cancer Inst. (1998) [Pubmed]
  43. Prescribed fenoterol and death from asthma in New Zealand, 1981-83: case-control study. Crane, J., Pearce, N., Flatt, A., Burgess, C., Jackson, R., Kwong, T., Ball, M., Beasley, R. Lancet (1989) [Pubmed]
  44. Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study. Eisen, A., Lubinski, J., Klijn, J., Moller, P., Lynch, H.T., Offit, K., Weber, B., Rebbeck, T., Neuhausen, S.L., Ghadirian, P., Foulkes, W.D., Gershoni-Baruch, R., Friedman, E., Rennert, G., Wagner, T., Isaacs, C., Kim-Sing, C., Ainsworth, P., Sun, P., Narod, S.A. J. Clin. Oncol. (2005) [Pubmed]
  45. The HRAS1 minisatellite locus and risk of ovarian cancer. Weitzel, J.N., Ding, S., Larson, G.P., Nelson, R.A., Goodman, A., Grendys, E.C., Ball, H.G., Krontiris, T.G. Cancer Res. (2000) [Pubmed]
WikiGenes - Universities