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Ishiwata, K. et al.

Ishiwata, Tsukada, Kubota, Nariai, Harada, Kawamura, Kimura, Oda, Iwata, Ishii,

Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography.

We performed preclinical and clinical studies of O-[11C]methyl-L-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-L-tyrosine and the acute toxicity and mutagenicity of O-methyl-L-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-L-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-L-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.[1]

References

Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography. Ishiwata, K., Tsukada, H., Kubota, K., Nariai, T., Harada, N., Kawamura, K., Kimura, Y., Oda, K., Iwata, R., Ishii, K. Nucl. Med. Biol. (2005) [Pubmed]

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