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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Apolipoprotein E activates the low-activity form of human phospholipid transfer protein.

Phospholipid transfer protein (PLTP) exists in a high-activity (HA-PLTP) and a low-activity form (LA-PLTP) in the circulation. LA-PLTP is associated with apoA-I while the HA-PLTP complex is enriched with apoE. To study the interaction of PLTP with apolipoproteins, we carried out surface plasmon resonance analyses. These demonstrated a concentration-dependent binding of recombinant human PLTP, which represents an active PLTP form, and LA-PLTP to apoE, apoA-I, and apoA-IV within a nanomolar K(D) range. To study whether LA-PLTP can be transformed into an active form, we incubated it in the presence of proteoliposomes containing apoE, apoA-I or apoA-IV. The apoE proteoliposomes induced a concentration-dependent activation of LA-PLTP. ApoA-IV proteoliposomes also activated LA-PLTP in a concentration-dependent manner, whereas apoA-I proteoliposomes had no such effect. These observations suggest that PLTP is capable of interacting with apoE, apoA-I, and apoA-IV, and that these interactions regulate PLTP-activity levels in plasma.[1]


  1. Apolipoprotein E activates the low-activity form of human phospholipid transfer protein. Jänis, M.T., Metso, J., Lankinen, H., Strandin, T., Olkkonen, V.M., Rye, K.A., Jauhiainen, M., Ehnholm, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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