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Gene Review

APOA4  -  apolipoprotein A-IV

Homo sapiens

Synonyms: Apo-AIV, ApoA-IV, Apolipoprotein A-IV, Apolipoprotein A4
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Disease relevance of APOA4


Psychiatry related information on APOA4


High impact information on APOA4


Chemical compound and disease context of APOA4

  • The accumulation of apolipoprotein A-IV in high density lipoproteins from patients with end-stage renal disease might reflect the impaired reversed cholesterol transport mechanisms which are believed to be a major cause of the high prevalence of atherosclerotic diseases in these patients [13].

Biological context of APOA4


Anatomical context of APOA4


Associations of APOA4 with chemical compounds


Physical interactions of APOA4


Regulatory relationships of APOA4


Other interactions of APOA4


Analytical, diagnostic and therapeutic context of APOA4


  1. The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease. Wong, W.M., Stephens, J.W., Acharya, J., Hurel, S.J., Humphries, S.E., Talmud, P.J. J. Lipid Res. (2004) [Pubmed]
  2. Response of apolipoprotein AIV and lipoproteins to glycaemic control in young people with insulin-dependent diabetes mellitus. Attia, N., Touzani, A., Lahrichi, M., Balafrej, A., Kabbaj, O., Girard-Globa, A. Diabet. Med. (1997) [Pubmed]
  3. Apolipoprotein AIV gene variant S347 is associated with increased risk of coronary heart disease and lower plasma apolipoprotein AIV levels. Wong, W.M., Hawe, E., Li, L.K., Miller, G.J., Nicaud, V., Pennacchio, L.A., Humphries, S.E., Talmud, P.J. Circ. Res. (2003) [Pubmed]
  4. A method to screen apolipoprotein polymorphisms in whole plasma: description of apolipoprotein A-IV variants in dyslipidemias and a reassessment of apolipoprotein A-I in Tangier disease. Bisgaier, C.L., Lee, E.S., Glickman, R.M. Biochim. Biophys. Acta (1987) [Pubmed]
  5. The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes. Kretowski, A., Hokanson, J.E., McFann, K., Kinney, G.L., Snell-Bergeon, J.K., Maahs, D.M., Wadwa, R.P., Eckel, R.H., Ogden, L.G., Garg, S.K., Li, J., Cheng, S., Erlich, H.A., Rewers, M. Diabetologia (2006) [Pubmed]
  6. Sensitivity of serum apolipoprotein A-IV levels to changes in dietary fat content. Weinberg, R.B., Dantzker, C., Patton, C.S. Gastroenterology (1990) [Pubmed]
  7. Association of the apolipoprotein A-IV codon 360 mutation in patients with Alzheimer's disease. Császár, A., Kálmán, J., Szalai, C., Janka, Z., Romics, L. Neurosci. Lett. (1997) [Pubmed]
  8. Intestinal expression of human apolipoprotein A-IV in transgenic mice fails to influence dietary lipid absorption or feeding behavior. Aalto-Setälä, K., Bisgaier, C.L., Ho, A., Kieft, K.A., Traber, M.G., Kayden, H.J., Ramakrishnan, R., Walsh, A., Essenburg, A.D., Breslow, J.L. J. Clin. Invest. (1994) [Pubmed]
  9. Protection against atherogenesis in mice mediated by human apolipoprotein A-IV. Duverger, N., Tremp, G., Caillaud, J.M., Emmanuel, F., Castro, G., Fruchart, J.C., Steinmetz, A., Denèfle, P. Science (1996) [Pubmed]
  10. Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein. Rader, D.J., Schäfer, J., Lohse, P., Verges, B., Kindt, M., Zech, L.A., Steinmetz, A., Brewer, H.B. J. Clin. Invest. (1993) [Pubmed]
  11. Disruption of hedgehog signaling reveals a novel role in intestinal morphogenesis and intestinal-specific lipid metabolism in mice. Wang, L.C., Nassir, F., Liu, Z.Y., Ling, L., Kuo, F., Crowell, T., Olson, D., Davidson, N.O., Burkly, L.C. Gastroenterology (2002) [Pubmed]
  12. Apolipoprotein synthesis in normal and abetalipoproteinemic intestinal mucosa. Glickman, R.M., Glickman, J.N., Magun, A., Brin, M. Gastroenterology (1991) [Pubmed]
  13. Plasma apolipoprotein A-IV metabolism in patients with chronic renal disease. Dieplinger, H., Lobentanz, E.M., König, P., Graf, H., Sandholzer, C., Matthys, E., Rosseneu, M., Utermann, G. Eur. J. Clin. Invest. (1992) [Pubmed]
  14. Common genomic variation in the APOC3 promoter associated with variation in plasma lipoproteins. Hegele, R.A., Connelly, P.W., Hanley, A.J., Sun, F., Harris, S.B., Zinman, B. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  15. DNA polymorphism haplotypes of the human apolipoprotein APOA1-APOC3-APOA4 gene cluster. Antonarakis, S.E., Oettgen, P., Chakravarti, A., Halloran, S.L., Hudson, R.R., Feisee, L., Karathanasis, S.K. Hum. Genet. (1988) [Pubmed]
  16. The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. Garasto, S., Rose, G., Derango, F., Berardelli, M., Corsonello, A., Feraco, E., Mari, V., Maletta, R., Bruni, A., Franceschi, C., Carotenuto, L., De Benedictis, G. Ann. Hum. Genet. (2003) [Pubmed]
  17. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. Dallongeville, J., Cottel, D., Montaye, M., Codron, V., Amouyel, P., Helbecque, N. International journal of cardiology. (2006) [Pubmed]
  18. Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Karathanasis, S.K., Oettgen, P., Haddad, I.A., Antonarakis, S.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  19. Role of apolipoprotein A-IV in hepatic lipase-catalyzed dolichol acylation and phospholipid hydrolysis. Sindelar, P.J., Chojnacki, I., Valtersson, C. Biochemistry (1997) [Pubmed]
  20. Peptide YY stimulates the expression of apolipoprotein A-IV gene in Caco-2 intestinal cells. Sonoyama, K., Suzuki, K., Kasai, T. Proc. Soc. Exp. Biol. Med. (2000) [Pubmed]
  21. Identification of a detergent-solubilized plasma membrane protein from rat liver recognizing apolipoprotein A-IV. Ghiselli, G., Crump, W., Musanti, R., Gotto, A.M. Biochim. Biophys. Acta (1990) [Pubmed]
  22. Apolipoprotein A-IV genetic polymorphism and its impact on quantitative traits in normoglycemic and non-insulin-dependent diabetic Hispanics from the San Luis Valley, Colorado. Kamboh, M.I., Iyengar, S., Aston, C.E., Hamman, R.F., Ferrell, R.E. Hum. Biol. (1992) [Pubmed]
  23. APOA1/C3/A4 gene cluster variability and lipid levels in Brazilian children. de França, E., Alves, J.G., Hutz, M.H. Braz. J. Med. Biol. Res. (2005) [Pubmed]
  24. Interaction of plasma proteins with heparinized gel particles studied by high-resolution two-dimensional gel electrophoresis. Ho, C.H., Hlady, V., Nyquist, G., Andrade, J.D., Caldwell, K.D. J. Biomed. Mater. Res. (1991) [Pubmed]
  25. Activation of lecithin: cholesterol acyltransferase by apolipoproteins E-2, E-3, and A-IV isolated from human plasma. Chen, C.H., Albers, J.J. Biochim. Biophys. Acta (1985) [Pubmed]
  26. Human apolipoprotein A-IV binds to apolipoprotein A-I/A-II receptor sites and promotes cholesterol efflux from adipose cells. Steinmetz, A., Barbaras, R., Ghalim, N., Clavey, V., Fruchart, J.C., Ailhaud, G. J. Biol. Chem. (1990) [Pubmed]
  27. Apolipoprotein E activates the low-activity form of human phospholipid transfer protein. Jänis, M.T., Metso, J., Lankinen, H., Strandin, T., Olkkonen, V.M., Rye, K.A., Jauhiainen, M., Ehnholm, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  28. E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: a role for the hepatic nuclear factor 4. Peignon, G., Thenet, S., Schreider, C., Fouquet, S., Ribeiro, A., Dussaulx, E., Chambaz, J., Cardot, P., Pinçon-Raymond, M., Le Beyec, J. J. Biol. Chem. (2006) [Pubmed]
  29. Stable isotope turnover of apolipoproteins of high-density lipoproteins in humans. Marsh, J.B., Welty, F.K., Schaefer, E.J. Curr. Opin. Lipidol. (2000) [Pubmed]
  30. Macrovascular disease is associated with increased plasma apolipoprotein A-IV levels in NIDDM. Vergès, B.L., Lagrost, L., Vaillant, G., Petit, J.M., Cohen, M., Gambert, P., Brun, J.M. Diabetes (1997) [Pubmed]
  31. Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Martin, S., Nicaud, V., Humphries, S.E., Talmud, P.J. Biochim. Biophys. Acta (2003) [Pubmed]
  32. Serum apolipoprotein A-IV and lipoprotein cholesterol in patients undergoing total parenteral nutrition. Sherman, J.R., Weinberg, R.B. Gastroenterology (1988) [Pubmed]
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