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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Switching between allosteric and dimerization inhibition of HIV-1 protease.

Refining the functional groups on a phenethylamine moiety within an inhibitor of HIV-1 protease led to a switch in the mechanism of inhibition from competitive and allosteric to dimerization inhibition. Phenylether extensions to the phenethylamine group led to agents that target the dimerization interface of HIV-1 protease with high potency.[1]

References

  1. Switching between allosteric and dimerization inhibition of HIV-1 protease. Bowman, M.J., Byrne, S., Chmielewski, J. Chem. Biol. (2005) [Pubmed]
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