Capacitative calcium entry: sensing the calcium stores.
A long-standing mystery in the cell biology of calcium channel regulation is the nature of the signal linking intracellular calcium stores to plasma membrane capacitative calcium entry channels. An RNAi-based screen of selected Drosophila genes has revealed that a calcium-binding protein, stromal interaction molecule ( STIM), plays an essential role in the activation of these channels and may be the long sought sensor of calcium store content.[1]References
- Capacitative calcium entry: sensing the calcium stores. Putney, J.W. J. Cell Biol. (2005) [Pubmed]
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