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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid.

The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication.[1]

References

  1. Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid. Capparelli, E.V., Letendre, S.L., Ellis, R.J., Patel, P., Holland, D., McCutchan, J.A. Antimicrob. Agents Chemother. (2005) [Pubmed]
 
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