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G Themelis, D. et al.

G Themelis, Trellopoulos, Tzanavaras, Karlberg,

Assay of the synthetic estrogen fosfestrol in pharmaceutical formulations using capillary electrophoresis.

This study reports--for the first time--a capillary electrophoretic method for the determination of fosfestrol, a synthetic estrogen used in the treatment of metastatic prostate cancer. The effects of the carrier ion concentration, injected volume and applied voltage were studied and optimized. A 10 mM sodium tetraborate solution was selected as the carrier electrolyte solution, while the sample was injected hydrodynamically by applying a 20 mmHg vacuum for 1 s. The driving voltage was 30 kV and the absorbance of the analyte (peak height) was monitored at 240 nm. Under the above-mentioned conditions, the migration time of fosfestrol was 6.6 min. Linearity was achieved in the analyte range 3-150 mgL(-1) with the detection limit being 1 mgL(-1). The proposed method is adequately precise (s(r)=2.8% at 100 mgL(-1) fosfestrol, n=10) without the use of an internal standard and was applied to the determination of fosfestrol in a pharmaceutical formulation. The results obtained by the proposed method were in good agreement with those derived from the USP reference method.[1]

References

Assay of the synthetic estrogen fosfestrol in pharmaceutical formulations using capillary electrophoresis. G Themelis, D., Trellopoulos, A.V., Tzanavaras, P.D., Karlberg, B. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]

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