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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells.

Cannabinoids have been shown to inhibit the growth of a broad spectrum of tumour cells. However, the molecular mechanisms involved in that effect have not been completely elucidated. Here, we investigated the possible involvement of mitogen-activated protein kinases (MAPKs) in CB2 receptor-induced apoptosis of human leukaemia cells. Results show that stimulation of the CB2 receptor leads to p38 MAPK activation and that inhibition of this kinase attenuates CB2 receptor-induced caspase activation and apoptosis. These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells.[1]

References

  1. p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells. Herrera, B., Carracedo, A., Diez-Zaera, M., Guzmán, M., Velasco, G. FEBS Lett. (2005) [Pubmed]
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