Gene Review:
MAPK14 - mitogen-activated protein kinase 14
Homo sapiens
Synonyms:
CSAID-binding protein, CSBP, CSBP1, CSBP2, CSPB1, ...
- Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Kim, H., Kokkotou, E., Na, X., Rhee, S.H., Moyer, M.P., Pothoulakis, C., Lamont, J.T. Gastroenterology (2005)
- Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus. Suomalainen, M., Nakano, M.Y., Boucke, K., Keller, S., Greber, U.F. EMBO J. (2001)
- Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Prasad, H.C., Zhu, C.B., McCauley, J.L., Samuvel, D.J., Ramamoorthy, S., Shelton, R.C., Hewlett, W.A., Sutcliffe, J.S., Blakely, R.D. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression. Wang, W.H., Grégori, G., Hullinger, R.L., Andrisani, O.M. Mol. Cell. Biol. (2004)
- Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines. Cardone, R.A., Bagorda, A., Bellizzi, A., Busco, G., Guerra, L., Paradiso, A., Casavola, V., Zaccolo, M., Reshkin, S.J. Mol. Biol. Cell (2005)
- Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Koistinaho, M., Koistinaho, J. Glia (2002)
- Active stress kinase p38 enhances and perpetuates abnormal tau phosphorylation and deposition in Pick's disease. Puig, B., Vinals, F., Ferrer, I. Acta Neuropathol. (2004)
- HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway. Missé, D., Esteve, P.O., Renneboog, B., Vidal, M., Cerutti, M., St Pierre, Y., Yssel, H., Parmentier, M., Veas, F. Blood (2001)
- Herpes simplex virus type 1 blocks the apoptotic host cell defense mechanisms that target Bcl-2 and manipulates activation of p38 mitogen-activated protein kinase to improve viral replication. Zachos, G., Koffa, M., Preston, C.M., Clements, J.B., Conner, J. J. Virol. (2001)
- p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci. Simone, C., Forcales, S.V., Hill, D.A., Imbalzano, A.N., Latella, L., Puri, P.L. Nat. Genet. (2004)
- Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Bulavin, D.V., Demidov, O.N., Saito, S., Kauraniemi, P., Phillips, C., Amundson, S.A., Ambrosino, C., Sauter, G., Nebreda, A.R., Anderson, C.W., Kallioniemi, A., Fornace, A.J., Appella, E. Nat. Genet. (2002)
- A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Takekawa, M., Saito, H. Cell (1998)
- Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Bulavin, D.V., Higashimoto, Y., Popoff, I.J., Gaarde, W.A., Basrur, V., Potapova, O., Appella, E., Fornace, A.J. Nature (2001)
- Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Evans, J.L., Goldfine, I.D., Maddux, B.A., Grodsky, G.M. Endocr. Rev. (2002)
- Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/p38 MAP kinase. Kumar, S., Orsini, M.J., Lee, J.C., McDonnell, P.C., Debouck, C., Young, P.R. J. Biol. Chem. (1996)
- Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines. Liem, A.A., Appleyard, M.V., O'Neill, M.A., Hupp, T.R., Chamberlain, M.P., Thompson, A.M. Br. J. Cancer (2003)
- Mxi2, a splice variant of p38 stress-activated kinase, is a distal nephron protein regulated with kidney ischemia. Faccio, L., Chen, A., Fusco, C., Martinotti, S., Bonventre, J.V., Zervos, A.S. Am. J. Physiol., Cell Physiol. (2000)
- Activation of p38 and N-acetylcysteine-sensitive c-Jun NH2-terminal kinase signaling cascades is required for induction of apoptosis in Parkinson's disease cybrids. Onyango, I.G., Tuttle, J.B., Bennett, J.P. Mol. Cell. Neurosci. (2005)
- Interleukin-8 secretion from Mycobacterium tuberculosis-infected monocytes is regulated by protein tyrosine kinases but not by ERK1/2 or p38 mitogen-activated protein kinases. Ameixa, C., Friedland, J.S. Infect. Immun. (2002)
- Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Han, J., Jiang, Y., Li, Z., Kravchenko, V.V., Ulevitch, R.J. Nature (1997)
- The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. Winzen, R., Kracht, M., Ritter, B., Wilhelm, A., Chen, C.Y., Shyu, A.B., Müller, M., Gaestel, M., Resch, K., Holtmann, H. EMBO J. (1999)
- p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation. Ramsauer, K., Sadzak, I., Porras, A., Pilz, A., Nebreda, A.R., Decker, T., Kovarik, P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Switching leukemia cell phenotype between life and death. Tucker, S.J., Rae, C., Littlejohn, A.F., Paul, A., MacEwan, D.J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells. Cuenda, A., Alonso, G., Morrice, N., Jones, M., Meier, R., Cohen, P., Nebreda, A.R. EMBO J. (1996)
- MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. Fukunaga, R., Hunter, T. EMBO J. (1997)
- Regulation of the maintenance of peripheral T-cell anergy by TAB1-mediated p38 alpha activation. Ohkusu-Tsukada, K., Tominaga, N., Udono, H., Yui, K. Mol. Cell. Biol. (2004)
- p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons. Goh, K.C., Haque, S.J., Williams, B.R. EMBO J. (1999)
- PRAK, a novel protein kinase regulated by the p38 MAP kinase. New, L., Jiang, Y., Zhao, M., Liu, K., Zhu, W., Flood, L.J., Kato, Y., Parry, G.C., Han, J. EMBO J. (1998)
- 3,3'-Diindolylmethane is a novel mitochondrial H(+)-ATP synthase inhibitor that can induce p21(Cip1/Waf1) expression by induction of oxidative stress in human breast cancer cells. Gong, Y., Sohn, H., Xue, L., Firestone, G.L., Bjeldanes, L.F. Cancer Res. (2006)
- The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells. Macfarlane, W.M., Smith, S.B., James, R.F., Clifton, A.D., Doza, Y.N., Cohen, P., Docherty, K. J. Biol. Chem. (1997)
- A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. Tanoue, T., Yamamoto, T., Maeda, R., Nishida, E. J. Biol. Chem. (2001)
- Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Zervos, A.S., Faccio, L., Gatto, J.P., Kyriakis, J.M., Brent, R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Chang, C.I., Xu, B.E., Akella, R., Cobb, M.H., Goldsmith, E.J. Mol. Cell (2002)
- Strength of TRAF6 signalling determines osteoclastogenesis. Kadono, Y., Okada, F., Perchonock, C., Jang, H.D., Lee, S.Y., Kim, N., Choi, Y. EMBO Rep. (2005)
- Detection of a novel unglycosylated form of hepatitis C virus E2 envelope protein that is located in the cytosol and interacts with PKR. Pavio, N., Taylor, D.R., Lai, M.M. J. Virol. (2002)
- Regulation of the MEF2 family of transcription factors by p38. Zhao, M., New, L., Kravchenko, V.V., Kato, Y., Gram, H., di Padova, F., Olson, E.N., Ulevitch, R.J., Han, J. Mol. Cell. Biol. (1999)
- Ischemic preconditioning: from adenosine receptor to KATP channel. Cohen, M.V., Baines, C.P., Downey, J.M. Annu. Rev. Physiol. (2000)
- Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells. Toivola, D.M., Zhou, Q., English, L.S., Omary, M.B. Mol. Biol. Cell (2002)
- Phosphorylation motifs regulating the stability and function of myocyte enhancer factor 2A. Cox, D.M., Du, M., Marback, M., Yang, E.C., Chan, J., Siu, K.W., McDermott, J.C. J. Biol. Chem. (2003)
- p38 alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cells. Schafer, P.H., Wadsworth, S.A., Wang, L., Siekierka, J.J. J. Immunol. (1999)
- Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. McLaughlin, M.M., Kumar, S., McDonnell, P.C., Van Horn, S., Lee, J.C., Livi, G.P., Young, P.R. J. Biol. Chem. (1996)
- Activation of discoidin domain receptor 1 facilitates the maturation of human monocyte-derived dendritic cells through the TNF receptor associated factor 6/TGF-beta-activated protein kinase 1 binding protein 1 beta/p38 alpha mitogen-activated protein kinase signaling cascade. Matsuyama, W., Faure, M., Yoshimura, T. J. Immunol. (2003)
- MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. Saha, R.N., Jana, M., Pahan, K. J. Immunol. (2007)
- The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation. Zhao, Q., Barakat, B.M., Qin, S., Ray, A., El-Mahdy, M.A., Wani, G., Arafa, E.S., Mir, S.N., Wang, Q.E., Wani, A.A. J. Biol. Chem. (2008)
- H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells. Shin, I., Kim, S., Song, H., Kim, H.R., Moon, A. J. Biol. Chem. (2005)
- 15-deoxy-Delta12,14-prostaglandin J2 inhibits IFN-inducible protein 10/CXC chemokine ligand 10 expression in human microglia: mechanisms and implications. Si, Q., Zhao, M.L., Morgan, A.C., Brosnan, C.F., Lee, S.C. J. Immunol. (2004)
- TNF receptor-associated factor-3 signaling mediates activation of p38 and Jun N-terminal kinase, cytokine secretion, and Ig production following ligation of CD40 on human B cells. Grammer, A.C., Swantek, J.L., McFarland, R.D., Miura, Y., Geppert, T., Lipsky, P.E. J. Immunol. (1998)
- p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades. Sharma, G.D., He, J., Bazan, H.E. J. Biol. Chem. (2003)
- Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. Wang, X.S., Diener, K., Manthey, C.L., Wang, S., Rosenzweig, B., Bray, J., Delaney, J., Cole, C.N., Chan-Hui, P.Y., Mantlo, N., Lichenstein, H.S., Zukowski, M., Yao, Z. J. Biol. Chem. (1997)
- Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. Rolli, M., Kotlyarov, A., Sakamoto, K.M., Gaestel, M., Neininger, A. J. Biol. Chem. (1999)